αamylase

α-Amylase, a hydrolase enzyme, catalyzes the hydrolysis of internal α-1,4-glycosidic linkages in starch, producing glucose and maltose.

Amylase (Diastase) is any one of a group of enzymes which catalyses the breakdown of starch into maltose.

Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway.Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect.

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can moderately inhibit α-amylase activity, with an IC50 value of 0.03 µmol/ml.

1. Rubusoside is a natural sweetener . 2. Rubusoside is a solubilizing agent with antiangiogenic and antiallergic properties.

7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.

8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside (Compound 3), a natural product isolated from Bidens bipinnata, exhibits 22% inhibition against α-amylase at a concentration of 0.556 mg/mL [1].

Quercetin 3-(6″-caffeoylsophoroside) is an orally active compound exhibiting α-amylase inhibitory activity with an IC50 value of 73.66 μg/mL, and demonstrates antidiabetic effects through the reduction of oxidative stress. It is found in the hydro-methanolic extract of Cardamine hirsuta Linn and is utilized in diabetes mellitus research [1].

Quercimeritrin (Quercetin-7-O-beta-D-glucopyranoside) has antibacterial activity, it shows promising activity against Staphylococcus aureus.

Stigmast-5-en-3-ol induces apoptosis in cancer cells and inhibits cellular proliferation by increasing the production of Bax, Caspase-9, p53, and promoting PARP cleavage, while reducing Bcl-xl expression. It exhibits potent inhibitory activity against glucose amylase and α-amylase (α-amylase), and demonstrates high antioxidant activity. This compound is applicable in research related to leukemia, breast cancer, type 2 diabetes, and obesity.

Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with the IC50 value of 7.9 ± 0.53 μM. Isookanin is a potent inhibitor of α-amylase (IC50=0.447 mg/ml).

Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena that inhibits α-amylase, α-glucosidase, and acetylcholinesterase. It exhibits neuroprotective activity, slowing amyloid β peptide-induced damage in differentiated neuronal cells SH-SY5Y, and can be used in the study of neurological disorders such as Alzheimer's disease.

Irilone is a flavonoid with α-amylase inhibitory activity and highly selective inhibition of CYP3A4. In addition, Irilone enhances progesterone receptor (PR) signaling via estrogen receptor (ER) and glucocorticoid receptor (GR) when combined with progesterone.Irilone has potential anti-inflammatory activity and inhibits nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 in mouse macrophages.

3,5,6,7,8,4′-hexamethoxyflavone is a natural product for research related to life sciences. The catalog number is TN7114 and the CAS number is 34170-18-8.