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Insulin-like Growth Factors, IGFs

The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (IGF-1) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. The IGF axis has been shown to play roles in the promotion of cell proliferation and the inhibition of cell death.

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Species
Canine (2)
Cynomolgus (3)
Human (29)
Mouse (10)
Rat (1)
Rhesus (2)
Rhesus macaque (1)
Expression System
Baculovirus-Insect Cells (2)
E. coli (5)
HEK293 (31)
Human Cells (7)
Yeast (3)
Tag
AVI (2)
C-6His (5)
C-6His-Avi (1)
C-Fc (1)
C-His (3)
C-His-Avi (1)
C-hFc (2)
GST (1)
His (19)
N-T7 tag (1)
N-hFc (2)
None (1)
Tag Free (7)
hFc (6)
Cat No. product name / Synonyms Species Expression System
TMPJ-00164 IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. M...
TMPJ-00345 IGF2BP-2 Protein, Human, Recombinant (His)
IGF2BP-2 Protein, Human, Recombinant (His)
Human E. coli
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains an...
TMPJ-00811 IGFBP-1 Protein, Human, Recombinant (His)
IGFBP-1 Protein, Human, Recombinant (His)
Human Human Cells
Insulin-like growth factor-binding protein 1 (IGFBP1) is encoded by 259 amino acid (aa) with 25 aa residue signal peptide that is processed to generate the 234 a...
TMPJ-01082 IGFBP-5 Protein, Mouse, Recombinant (His)
IGFBP-5 Protein, Mouse, Recombinant (His)
Mouse Human Cells
Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP ...
TMPJ-01161 CTGF/CCN2 Protein, Human, Recombinant
CTGF/CCN2 Protein, Human, Recombinant
Human Human Cells
CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF c...
TMPJ-01162 CTGF/CCN2 Protein, Human, Recombinant (hFc)
CTGF/CCN2 Protein, Human, Recombinant (hFc)
Human Human Cells
CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF c...
TMPJ-01163 CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)
CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)
Human Human Cells
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN pr...
TMPJ-01166 IGFBP-7 Protein, Mouse, Recombinant (His)
IGFBP-7 Protein, Mouse, Recombinant (His)
Mouse Human Cells
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-termina...
TMPK-00061 IGF2/IGF-II Protein, Human, Recombinant (hFc)
IGF2/IGF-II Protein, Human, Recombinant (hFc)
Human HEK293
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and ...
TMPK-00083 IGF1/IGF-I Protein, Human, Recombinant (hFc)
IGF1/IGF-I Protein, Human, Recombinant (hFc)
Human HEK293
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and ...
TMPK-00549 IGFBP-2 Protein, Cynomolgus, Recombinant (His)
IGFBP-2 Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293
Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as an IGF system regulator, controlling the distribution, function, and...
TMPK-00672 CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His)
CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His)
Rhesus macaque HEK293
Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other gro...
TMPK-00838 IGFBP-2 Protein, Human, Recombinant (His)
IGFBP-2 Protein, Human, Recombinant (His)
Human HEK293
Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as an IGF system regulator, controlling the distribution, function, and...
TMPK-01000 CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated
CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293
Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other gro...
TMPK-01027 IGFBP-7 Protein, Mouse, Recombinant (hFc)
IGFBP-7 Protein, Mouse, Recombinant (hFc)
Mouse HEK293
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein t...
TMPK-01371 IGFBP-7 Protein, Human, Recombinant (hFc)
IGFBP-7 Protein, Human, Recombinant (hFc)
Human HEK293
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein t...
TMPY-00080 IGFBP-1 Protein, Canine, Recombinant (His)
IGFBP-1 Protein, Canine, Recombinant (His)
Canine HEK293
IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding...
TMPY-00150 IGF2/IGF-II Protein, Human, Recombinant
IGF2/IGF-II Protein, Human, Recombinant
Human Yeast
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is ...
TMPY-00339 IGFL2 Protein, Human, Recombinant (hFc)
IGFL2 Protein, Human, Recombinant (hFc)
Human HEK293
IGFL2 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 38.9 kDa. Accession number: Q6UWQ7-2
TMPY-00508 IGFBP-5 Protein, Canine, Recombinant (hFc)
IGFBP-5 Protein, Canine, Recombinant (hFc)
Canine HEK293
IGFBP-5 Protein, Canine, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 55.5 kDa. Accession number: F1PEQ5
IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00164
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. M...
IGF2BP-2 Protein, Human, Recombinant (His)
TMPJ-00345
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains an...
IGFBP-1 Protein, Human, Recombinant (His)
TMPJ-00811
Insulin-like growth factor-binding protein 1 (IGFBP1) is encoded by 259 amino acid (aa) with 25 aa residue signal peptide that is processed to generate the 234 a...
IGFBP-5 Protein, Mouse, Recombinant (His)
TMPJ-01082
Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP ...
CTGF/CCN2 Protein, Human, Recombinant
TMPJ-01161
CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF c...
CTGF/CCN2 Protein, Human, Recombinant (hFc)
TMPJ-01162
CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF c...
CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)
TMPJ-01163
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN pr...
IGFBP-7 Protein, Mouse, Recombinant (His)
TMPJ-01166
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-termina...
IGF2/IGF-II Protein, Human, Recombinant (hFc)
TMPK-00061
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and ...
IGF1/IGF-I Protein, Human, Recombinant (hFc)
TMPK-00083
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and ...
IGFBP-2 Protein, Cynomolgus, Recombinant (His)
TMPK-00549
Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as an IGF system regulator, controlling the distribution, function, and...
CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His)
TMPK-00672
Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other gro...
IGFBP-2 Protein, Human, Recombinant (His)
TMPK-00838
Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as an IGF system regulator, controlling the distribution, function, and...
CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01000
Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other gro...
IGFBP-7 Protein, Mouse, Recombinant (hFc)
TMPK-01027
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein t...
IGFBP-7 Protein, Human, Recombinant (hFc)
TMPK-01371
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein t...
IGFBP-1 Protein, Canine, Recombinant (His)
TMPY-00080
IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding...
IGF2/IGF-II Protein, Human, Recombinant
TMPY-00150
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is ...
IGFL2 Protein, Human, Recombinant (hFc)
TMPY-00339
IGFL2 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 38.9 kDa. Accession number: Q6UWQ7-2
IGFBP-5 Protein, Canine, Recombinant (hFc)
TMPY-00508
IGFBP-5 Protein, Canine, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 55.5 kDa. Accession number: F1PEQ5
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TargetMol