The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (IGF-1) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. The IGF axis has been shown to play roles in the promotion of cell proliferation and the inhibition of cell death.
Cat No. | product name / Synonyms | Species | Expression System |
---|---|---|---|
TMPJ-00164 | IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
IGFBP-5 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | Human Cells |
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. M... | |||
TMPJ-00345 | IGF2BP-2 Protein, Human, Recombinant (His)
IGF2BP-2 Protein, Human, Recombinant (His)
|
Human | E. coli |
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains an... | |||
TMPJ-00811 | IGFBP-1 Protein, Human, Recombinant (His)
IGFBP-1 Protein, Human, Recombinant (His)
|
Human | Human Cells |
Insulin-like growth factor-binding protein 1 (IGFBP1) is encoded by 259 amino acid (aa) with 25 aa residue signal peptide that is processed to generate the 234 a... | |||
TMPJ-01082 | IGFBP-5 Protein, Mouse, Recombinant (His)
IGFBP-5 Protein, Mouse, Recombinant (His)
|
Mouse | Human Cells |
Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP ... | |||
TMPJ-01161 | CTGF/CCN2 Protein, Human, Recombinant
CTGF/CCN2 Protein, Human, Recombinant
|
Human | Human Cells |
CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF c... | |||
TMPJ-01162 | CTGF/CCN2 Protein, Human, Recombinant (hFc)
CTGF/CCN2 Protein, Human, Recombinant (hFc)
|
Human | Human Cells |
CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF c... | |||
TMPJ-01163 | CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)
CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)
|
Human | Human Cells |
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN pr... | |||
TMPJ-01166 | IGFBP-7 Protein, Mouse, Recombinant (His)
IGFBP-7 Protein, Mouse, Recombinant (His)
|
Mouse | Human Cells |
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-termina... | |||
TMPK-00061 | IGF2/IGF-II Protein, Human, Recombinant (hFc)
IGF2/IGF-II Protein, Human, Recombinant (hFc)
|
Human | HEK293 |
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and ... | |||
TMPK-00083 | IGF1/IGF-I Protein, Human, Recombinant (hFc)
IGF1/IGF-I Protein, Human, Recombinant (hFc)
|
Human | HEK293 |
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and ... | |||
TMPK-00549 | IGFBP-2 Protein, Cynomolgus, Recombinant (His)
IGFBP-2 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as an IGF system regulator, controlling the distribution, function, and... | |||
TMPK-00672 | CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His)
CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His)
|
Rhesus macaque | HEK293 |
Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other gro... | |||
TMPK-00838 | IGFBP-2 Protein, Human, Recombinant (His)
IGFBP-2 Protein, Human, Recombinant (His)
|
Human | HEK293 |
Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as an IGF system regulator, controlling the distribution, function, and... | |||
TMPK-01000 | CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated
CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other gro... | |||
TMPK-01027 | IGFBP-7 Protein, Mouse, Recombinant (hFc)
IGFBP-7 Protein, Mouse, Recombinant (hFc)
|
Mouse | HEK293 |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein t... | |||
TMPK-01371 | IGFBP-7 Protein, Human, Recombinant (hFc)
IGFBP-7 Protein, Human, Recombinant (hFc)
|
Human | HEK293 |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein t... | |||
TMPY-00080 | IGFBP-1 Protein, Canine, Recombinant (His)
IGFBP-1 Protein, Canine, Recombinant (His)
|
Canine | HEK293 |
IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding... | |||
TMPY-00150 | IGF2/IGF-II Protein, Human, Recombinant
IGF2/IGF-II Protein, Human, Recombinant
|
Human | Yeast |
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is ... | |||
TMPY-00339 | IGFL2 Protein, Human, Recombinant (hFc)
IGFL2 Protein, Human, Recombinant (hFc)
|
Human | HEK293 |
IGFL2 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 38.9 kDa. Accession number: Q6UWQ7-2 | |||
TMPY-00508 | IGFBP-5 Protein, Canine, Recombinant (hFc)
IGFBP-5 Protein, Canine, Recombinant (hFc)
|
Canine | HEK293 |
IGFBP-5 Protein, Canine, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 55.5 kDa. Accession number: F1PEQ5 |