Peucedanum

1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 induced NOX activation and Smad signaling. 3. Decursin has anti-cancer activity , mediated suppression of the PKCα, MAPK and NF-κB pathways in MCF-7 cells. 4. Decursin exhibits cytotoxicity against various human cancer cells and to possess anti-amnesic activity in vivo through the inhibition of AChE activity.

1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.

DL-Mannitol is a osmotic diuretic, it may play a role in reducing off-target 68Ga-PSMA renal uptake

1. Nodakenetin ((-)-Prangeferol) has clinical efficacy.

D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. D-Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activity. 2. Praeruptorin D and E can prot

Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis.

(+)-Pteryxin ((+)-Pteryxin) has muscle-relaxant props. (+)-Pteryxin shows hepatoprotective and nitric oxide prodn. inhibitory activity.

1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors and regulating the Bcl-2 family. 3.

Ostruthin (Ostruthine) is a natural coumarin with antimicrobial activity that can effectively inhibit the growth of a wide range of mycobacteria with a minimum inhibitory concentration of MIC= 3.4-107.4 μM.

cis-Methylkhellactone is a natural product for research related to life sciences. The catalog number is TN3667 and the CAS number is 20107-13-5.

Decuroside I shows weak inhibiting activity against the primary and secondary wave aggregation of human platelet.

(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.

Peucedanocoumarin II shows only partial relaxation.

Qianhucoumarin E is a natural product of Peucedanum, Apiaceae. The catalog number is TN4873 and the CAS number is 156041-02-0. Qianhucoumarin E can be used as a reference standard.

Apiosylskimmin is a natural product from Angelica gigas.

Peucedanocoumarin Ⅲ can induce rice resistance to blast disease.

Decursitin D is a natural product from the roots of Peucedanum decursivum.

Peucedanol 7-O-glucoside is a natural product for research related to life sciences. The catalog number is TN4759 and the CAS number is 65853-04-5.

trans-3'-O-Benzoyl-4'-O-methylkhellactone is a natural product for research related to life sciences. The catalog number is TN5163 and the CAS number is 23733-95-1.

Qianhucoumarin A is a natural product of Peucedanum, Apiaceae. The catalog number is TN4880 and the CAS number is 150135-35-6. Qianhucoumarin A can be used as a reference standard.

trans-Khellactone is a natural product from Peucedanum wulongense.

Oroselol, jatamansinol, nardostachysin, jatamansinone and nardosinone are Nardostachys jatamansi rhizome extract marker compounds.

Peucedanol 3'-O-glucoside is a natural product for research related to life sciences. The catalog number is TN4758 and the CAS number is 65891-61-4.