Gentiana

1. 6'-O-beta-D-Glucosylgentiopicroside (6'-O-Glucosylgentiopicroside) may have antifungal activity.

1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.

Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.

Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis

Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; has antianti-inflammatoryand antioxidative effects.

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta, exhibiting antispasmodic and anti-inflammatory activities. Dimethylbellidifolin shows mutagenicity in Salmonella typhimurium TA100, TA98, TA97, and TA2637 by the preincubation method and significantly inhibits the growth of Staphylococcus aureus at a dose of 200 µg/disk.

Gentianose is a carbohydrate reserve derived from perennial yellow gentian storage roots.

Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.

2,5-Dihydroxybenzoic acid (Gentisic acid) is an active metabolite of salicylic acid degradation with a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.

Bellidifolin (Bellidifoline) has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway. Bellidifolin shows interesting inhibitory activity of monoamine oxidases (MAO) A, it could be useful for treating type-2 diabetes, likely via the improvement of insulin resistance (IR). Bellidifolin also shows an antifungal effect (MIC values of 50 microg/mL).

Hop-17(21)-en-3-ol is a natural product of Gentiana, Gentianaceae. The catalog number is TN4225 and the CAS number is 564-14-7. Hop-17(21)-en-3-ol can be used as a reference standard.

2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.

Erythrocentaurin is a natural 2,3-dihydroisocoumarin compound. Erythrocentaurin is a novel hepatitis B virus inhibitor with an IC₅₀ of 12.5 μM. Erythrocentaurin also exhibits α-amylase inhibitory activity, with an IC₅₀ of 45.2 μM.

Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL.

1-Hydroxy-2,3,4,7-tetramethoxyxanthone, with an EC50 value of 6.6±1.4 µM, has vasodilatory action in coronary arteries pre-contracted with 1 µM 5-hydroxytryptamine (5-HT) and can effectively inhibit osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells.

Glucocaffeic acid is a phenolic natural product suitable for biochemical experiments and drug synthesis research.

Trifloroside is a bitter iridoid glycoside.

Gentiournoside D is a natural product from Gentiana urnula.

Gelidoside is a natural product from Gentiana siphonantha.

Depressine is a cycloaromatic triterpenoid glycoside isolated from Gentiana depressa, suitable for biochemical experiments and drug synthesis research.

Erythrocentauric acid is a natural product from Gentiana macrophylla.

1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone is a natural product for research related to life sciences. The catalog number is TN2472 and the CAS number is 1890153-71-5.

Macrophylloside D is a natural product for research related to life sciences. The catalog number is TN6558 and the CAS number is 179457-69-3.

2-Methoxyanofinic acid is active against the plant pathogenic fungus Cladosporium cucumerinum.