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Natural Product Categories Natural Product Categories Austrobaileyales
Austrobaileyales is one of the earliest-diverging lineages of extant angiosperms, representing a critical window into the origin and early evolution of flowering plants. This order includes species that produce unique secondary metabolites such as essential oils, phenylpropanoids, and primitive alkaloid-like compounds. In biomedical research, Austrobaileyales is significant not only for its limited but chemically informative metabolite profile, but also for its role in reconstructing the evolutionary history of plant-derived pharmacologically active compounds. Its phylogenetic position helps researchers understand how complex biosynthetic pathways evolved in angiosperms, providing insight into the ancestral chemical space from which modern medicinal plants diversified. Although underexplored, Austrobaileyales offers valuable potential for discovering novel bioactive scaffolds.
- 5-O-Caffeoylshikimic acidTN129573263-62-45-O-Caffeoylshikimic acid is a caffeoylated derivative of shikimic acid and belongs to the class of natural polyphenolic compounds; it is widely found in plants such as Smilax glabra. 5-O-Caffeoylshikimic acid exhibits antioxidant and anti-inflammatory activity. 5-O-Caffeoylshikimic acid can be used in research related to non-small cell lung cancer (NSCLC).
- $98
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Cited - Angeloylgomisin HTN101866056-22-2Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.
- $50
SizeQTY - Schisandrin BWuweizisu-B, Schizandrin B, Schisandrin B (Sch B), gamma-SchisandrinT292561281-37-6Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.
- $35
SizeQTY Cited - Schisandrol BWuweizi alcohol-B, TJN-101, Schizandrol B, Gomisin A, Gamma-Schisandrin, BesigomsinT6S191758546-54-61. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Schisandrol B induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Schisandrol B significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.
- $65
SizeQTY - Schisantherin ESchizantherin-ET3S192564917-83-5Schisantherin E is a natural lignan isolated from Schisandra chinensis. Schisandra chinensis has antioxidant, hepatoprotective, sedative, anticancer, anti-SARS and anti-inflammatory activities.
- $64
SizeQTY - MacelignanAnwuligan, (+)-AnwulignanT3866107534-93-0Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.
- $33
SizeQTY - Schisandrin CWuweizisu-C, Schizandrin-CT5S192361301-33-5Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
- $40
SizeQTY Cited - SchisandroneArisantetralone CTN111698619-25-1Schisandrone (Arisantetralone C) is a 4-aryltetrahydrofuran lignan extracted from the dried fruit of Schisandra chinensis.
- $58
SizeQTY - Heteroclitin DT3S1916140369-76-21. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor.
- $59
SizeQTY - ChamigrenalT3P285519912-84-6β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50)
- $80
SizeQTY - IsomagnoloneTN1785155709-41-4Isomagnolone is a natural product isolated from Illicium burmanicum and has anti-inflammatory activity.
- $161
SizeQTY - Schisantherin AWuweizi ester-A, Schizantherin-A, Schisanwilsonin H, Gomisin-C, Arisanschinin KT291358546-56-8Schisantherin A (Wuweizi ester-A) is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent.
- $43
SizeQTY Cited - Tigloylgomisin HTN227266069-55-4Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer that specifically upregulates phase
- $48
SizeQTY - (-)-Denudatin BDenudatin BTN383187402-88-8(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin.
- $85
SizeQTY - Schisantherin BWuweizi ester-B, Schizantherin-B, Gomisin-BT6S191858546-55-71. Schisantherin B (Schizantherin-B) shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis.
- $32
SizeQTY - 3,4-O-Isopropylidene-shikimic acid3,4-O-Isopropylidene shikimic acidTN1238183075-03-83,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) exhibits significant anti-inflammatory, anti-thrombosis, antioxidant, and analgesic effects, and provides protective benefits against trinitrobenzenesulfonic acid-induced experimental colitis in rats, likely because of its antioxidant properties.
- $68
SizeQTY - SchisandrinWuweizichun-A, Wuweizi alcohol-A, Schizandrol-A, SchizandrolT29507432-28-2Schisandrin (Wuweizi alcohol-A) is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.
- $30
SizeQTY Cited - Angeloylgomisin QTN139072561-28-5Angeloylgomisin Q is a natural product from Schizandra chinensis BAILL.
- $190
SizeQTY - KadsurinTN181651670-40-7Kadsurin has anti-oxidant activity, it induces enzymes capable of scavenging oxygen radical species in the liver. Kadsurin may be valuable antitumor promoters or chemopreventors.
- $106
SizeQTY - Gomisin GTQ021762956-48-3Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
- $64
SizeQTY - SchisanhenolSchizanhenol, Gomisin-K3T6S193069363-14-01. Schisanhenol (Schizanhenol) can protect against adriamycin induced heart mitochondrial toxicity. 2. Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals. 3. Schisanhenol has anti-apoptosis effect on BACSs, may be related to its inhibition of ROS generation.
- $47
SizeQTY - Gomisin O5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-olTN170972960-22-6Gomisin O (5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-ol) is a natural product from Schizandra chinensis.
- $98
SizeQTY - Methyl syringateSyringic Acid Methyl EsterT3727884-35-5Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selective activator of hTRPA1, can regulate food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression.
- $33
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