Aristolochia

Aristolochic acid A is the main component of the plant extract aristolochic acids, primarily found in the herbaceous plants Aristolochia and Asarum. It significantly inhibits the activity of activator protein 1 (AP-1) and NF-κB, and downregulates the expression of the bladder cancer-associated BLCAP gene in human cells. It is commonly used to induce nephrotoxicity models.

Isostearic acid (Isooctadecanoic acid) is an active ingredient in imiquimod formulations that promotes the entry of imiquimod or peripherally secreted cytokines into the brain, and can be used to induce psoriasis-like disease models.

Aristolochic acid C, a derivative of Aristolochic acid, acts as a phospholipase A2 inhibitor.

1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF-beta1 pathway. 3. Aristololactam I may be one of toxic metabolites in Chinese herbs containing AA which participate in renal damage and fibrosis.

Aristolone (Aristofone) has potential anti-cancer activity.

Aristolochic Acid D, a derivative of aristolochic acid isolated from the stems of Aristolochia indica, is identified as both a carcinogen and nephrotoxin.

7-Hydroxyaristolochic acid A is a natural derivative of aristolochic acid. Aristolochic acid is nephrotoxic and carcinogenic, inhibits APE1/Nrf2/HO-1 axis-induced oxidative stress and apoptosis leading to nephrotoxicity, and induces apoptosis in NRK-52E cells via COX-2 and PGE2.

Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.

Undec-1-Ene is an alkene widely used in biochemical experiments and drug synthesis research.

Dodecane is a straight-chain alkane primarily used as a fuel, reference standard substance, and solvent, capable of upregulating TNF-α expression in rat skin irritation.

Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of platelet aggregation induced by collagen or arachidonic acid.

Eicosyl ferulate is a natural product of Aristolochia, Aristolochiaceae. The catalog number is TN1602 and the CAS number is 133882-79-8. Eicosyl ferulate can be used as a reference standard.

Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.

Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effects against tyrosinase mushroom. Aristolactam BII also exerts its significant neuroprotective ef

Aristolactam AIa is a natural product for research related to life sciences. The catalog number is TN6034 and the CAS number is 97399-90-1.

A natural compound from the herbs of Aristolochia debilis Sieb. et Zucc

Aristolindiquinone is a natural product

(-)-Holostyligone is a natural product

Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro.