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VDAC

Voltage-dependent anion channels, or mitochondrial porins, are a class of porin ion channel located on the outer mitochondrial membrane. There is debate as to whether or not this channel is expressed in the cell surface membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30–40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules.
Cat No. product name
T1765 Erastin Erastin is a ferroptosis activator acting on mitochondrial VDAC. It induces ferroptotic cell death in vitro.
T18975 DIDS sodium salt DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
T3572 NSC 15364 1, 3-Bis(4-aminophenyl)urea can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System.
Erastin
T1765
Erastin is a ferroptosis activator acting on mitochondrial VDAC. It induces ferroptotic cell death in vitro.
DIDS sodium salt
T18975
DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
NSC 15364
T3572
1, 3-Bis(4-aminophenyl)urea can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System.