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OX Receptor

The orexin receptor is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6155 Almorexant hydrochloride 913358-93-7 98%
Almorexant hydrochloride
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of...
T11186 EMPA 680590-49-2 99.91%
EMPA
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectiv...
T16854 SB-674042 483313-22-0 99.9%
SB-674042
SB-674042 is a potent and selective dual antagonist of the non-peptide orexigenic peptides OX1 and OX2 receptors, with IC50s of 3.76 nM and 531 nM, respectively....
T3722 MK-1064 1207253-08-4 99.88%
MK-1064
MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).
T12877L Seltorexant 1293281-49-8 99.83%
Seltorexant
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective...
T2710 TCS 1102 916141-36-1 99.76%
TCS 1102
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
T5500 DORA-22 1088991-95-0 99.73%
DORA-22
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
T6140 SB-334867 free base 792173-99-0 99.69%
SB-334867 free base
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.
T5498 SB-649868 380899-24-1 99.58%
SB-649868
SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
T26559 ACT-462206 1361321-96-1 99.45%
ACT-462206
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studi...
T16096 Filorexant 1088991-73-4 99.33%
Filorexant
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
T3177 Orexin 2 Receptor Agonist 1796565-52-0 99.14%
Orexin 2 Receptor Agonist
Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
T4965 TCS-OX2-29 372523-75-6 99.08%
TCS-OX2-29
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
T39229 YNT-185 1804978-81-1 98.6%
YNT-185
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectivel...
T1913 MK-3697 1224846-01-8 98.15%
MK-3697
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
T6658 SB-408124 288150-92-5 98.14%
SB-408124
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over...
T5503 IPSU 1373765-19-5 98.1%
IPSU
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
T2613 Almorexant 871224-64-5 98.02%
Almorexant
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and...
T67782 Daridorexant hydrochloride 1792993-84-0 98%
Daridorexant hydrochloride
Daridorexant hydrochloride (Nemorexant hydrochloride) is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research.
TP1045L Orexin B, rat, mouse Acetate TP1045L 94.61%
Orexin B, rat, mouse Acetate
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
Almorexant hydrochloride
T6155
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of...
EMPA
T11186
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectiv...
SB-674042
T16854
SB-674042 is a potent and selective dual antagonist of the non-peptide orexigenic peptides OX1 and OX2 receptors, with IC50s of 3.76 nM and 531 nM, respectively....
MK-1064
T3722
MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).
Seltorexant
T12877L
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective...
TCS 1102
T2710
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
DORA-22
T5500
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
SB-334867 free base
T6140
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.
SB-649868
T5498
SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
ACT-462206
T26559
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studi...
Filorexant
T16096
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
Orexin 2 Receptor Agonist
T3177
Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
TCS-OX2-29
T4965
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
YNT-185
T39229
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectivel...
MK-3697
T1913
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
SB-408124
T6658
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over...
IPSU
T5503
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
Almorexant
T2613
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and...
Daridorexant hydrochloride
T67782
Daridorexant hydrochloride (Nemorexant hydrochloride) is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research.
Orexin B, rat, mouse Acetate
TP1045L
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
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TargetMol