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OX Receptor

The orexin receptor is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2).
Cat. No. Product name CAS No. Purity Chemical Structure
T6155 Almorexant hydrochloride 913358-93-7 98%
Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 ...
TP1973L OXA (17-33) acetate 98%
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
TP1045L Orexin B, rat, mouse Acetate TP1045L 98%
Orexin B, rat, mouse Acetate is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
T67782 Daridorexant hydrochloride 1792993-84-0 98%
Daridorexant hydrochloride is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research.
T2613 Almorexant 871224-64-5 98%
Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respect...
T5503 IPSU 1373765-19-5 98%
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
T6658 SB-408124 288150-92-5 98%
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over...
T1913 MK-3697 1224846-01-8 98%
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
T39229 YNT-185 1804978-81-1 98%
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectivel...
T4965 TCS-OX2-29 372523-75-6 98%
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
T16096 Filorexant 1088991-73-4 98%
Filorexant is an orally bioavailable effective and selective reversible OX1 and OX2 receptor antagonist (<3 nM in binding).
T3177 Orexin 2 Receptor Agonist 1796565-52-0 98%
Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
T5498 SB-649868 380899-24-1 98%
SB-649868 is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
T3347 PF3274167 900510-03-4 98%
PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
T5500 DORA-22 1088991-95-0 98%
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
T2710 TCS 1102 916141-36-1 98%
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
T12877L Seltorexant 1293281-49-8 98%
Seltorexant crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 recep...
T3722 MK-1064 1207253-08-4 98%
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA).
T11186 EMPA 680590-49-2 98%
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectiv...
T6140 SB-334867 free base 792173-99-0 98%
SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
Almorexant hydrochloride
T6155
Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 ...
OXA (17-33) acetate
TP1973L
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
Orexin B, rat, mouse Acetate
TP1045L
Orexin B, rat, mouse Acetate is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
Daridorexant hydrochloride
T67782
Daridorexant hydrochloride is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research.
Almorexant
T2613
Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respect...
IPSU
T5503
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
SB-408124
T6658
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over...
MK-3697
T1913
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
YNT-185
T39229
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectivel...
TCS-OX2-29
T4965
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
Filorexant
T16096
Filorexant is an orally bioavailable effective and selective reversible OX1 and OX2 receptor antagonist (<3 nM in binding).
Orexin 2 Receptor Agonist
T3177
Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
SB-649868
T5498
SB-649868 is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
PF3274167
T3347
PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
DORA-22
T5500
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
TCS 1102
T2710
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
Seltorexant
T12877L
Seltorexant crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 recep...
MK-1064
T3722
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA).
EMPA
T11186
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectiv...
SB-334867 free base
T6140
SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
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