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Metabolism

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(88)

Glyoxalase

(17)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(100)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(240)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(94)

Stearoyl-CoA Desaturase (SCD)

NADPH

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent. It is used by all forms of cellular life.NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety. This extra phosphate is added by NAD+ kinase and removed by NADP+ phosphatase.

Filter HomeSignaling PathwaysMetabolismNADPH

Resveratrol

trans-Resveratrol, SRT 501

T1558501-36-0

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.

Antibacterial Antibiotic Antifungal Apoptosis Autophagy COX DNA/RNA Synthesis IκB/IKK Lipoxygenase Mitophagy NADPH Nrf2 Sirtuin

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Nrf2-ARE/hMAO-B/QR2 modulator 1

T603953035124-25-2

Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.

MAO Monoamine Oxidase NADPH Nrf2 Reactive Oxygen Species ROS

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NAD+

β-Nicotinamide Adenine Dinucleotide, β-NAD, β-DPN, DPN, Cozymase

T160953-84-9

NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).

Endogenous Metabolite NADPH

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G6PD activator AG1

T11347421581-52-4In house

G6PD activator AG1 is a glucose-6-phosphate dehydrogenase (G6PD) agonist that promotes glucose-6-phosphate dehydrogenase (G6PD) oligomerization to a catalytically competent form. G6PD activator AG1 reduces oxidative stress in cells and zebrafish, reduces chloroquine or diamide-induced oxidative stress in human erythrocytes, and can be used to study glucose-6-phosphate dehydrogenase deficiency.

Dehydrogenase NADPH Others

$273

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Metronidazole

Metronidazol, Flagyl, Anagiardil

T1079443-48-1

Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.

Antibacterial Antibiotic Antifection Apoptosis Hydrogenase NADPH Parasite

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Ubiquinone-1

CoQ1, Coenzyme Q1

T19594727-81-1

Ubiquinone-1 (UQ-1) is an intermediate in the biosynthesis of coenzyme Q, an essential coenzyme in the body's redox reactions, involved in multiple oxidation-reduction processes.

Endogenous Metabolite NADPH

$105

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GSK2795039

T154331415925-18-6

GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).

Apoptosis NADPH Reactive Oxygen Species ROS

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Diphenyleneiodonium chloride

DPI

T71914673-26-1

Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.

NADPH NOS Reactive Oxygen Species ROS TRP/TRPV Channel

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HTS07545

T61316118666-03-8

HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM) that reduces the rate of hydrogen sulfide (H2S) decomposition and has been used in heart failure studies.

Mitochondrial Metabolism NADPH Others

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S07-2010

S072010

T614851223194-71-5

S07-2010 is an AKR1C3 inhibitor with potential anti-cancer activity, suppressing AKR1C3, AKR1C4, AKR1C1, and AKR1C2, inducing apoptosis in A549/DDP cells. S07-2010 exhibits significant cytotoxicity in MCF-7/DOX and A549/DDP.

NADPH Others Reductase

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Luteolinidin chloride

TN18951154-78-5

Luteolinidin chloride is a natural product. It is a potent CD38 inhibitor which can protect the heart against I/R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo.

CD38 NADPH Tyrosinase

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KL1333

NQO1 activator 1

T163421800405-30-4

KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.

Mitochondrial Metabolism NADPH Reductase

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Mulberrofuran G

TN195687085-00-5

Mulberrofuran G, isolated from Morus alba L., has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death. Mulberrofuran G is a dual inhibitor of PTP1B and alpha-glucosidase for use in the study of Alzheimer's disease.

Apoptosis Caspase Glucosidase HBV JAK NADPH PARP Phosphatase ROS SARS-CoV STAT Tyrosinase

$222

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Hydroxy-PP-Me

T79878833481-77-9

Hydroxy-PP-Me is a potent and specific CBR1 inhibitor with an IC50 of 759 nM. It inhibits serum-withdrawal-induced apoptosis and, when used in conjunction with As2O3, enhances As2O3-induced apoptotic cell death [1] [2].

Apoptosis NADPH ROS

$199

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AKR1C1-IN-1

T141514906-68-7

AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).

NADPH Others Reductase

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ML-090

Fluoflavine

T22990531-46-4In house

ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM).

NADPH NADPH-oxidase

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Nordihydrocapsaicin

T342128789-35-7

Nordihydrocapsaicin is an analog and congener of capsaicin, belonging to the capsaicinoid class of compounds found in Capsicum chili peppers.

NADPH Nrf2 Others

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GLX351322

T8107835598-94-2

GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.

NADPH NADPH-oxidase

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Apocynin

NSC 2146, Acetovanillone, Acetoguaiacone

T6391498-02-2

Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).

Apoptosis Autophagy NADPH

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Quercetin-3-O-glucose-6''-acetate

6"-O-Acetylisoquercitrin

TN212654542-51-7

Quercetin-3-O-glucose-6''-acetate (6"-O-Acetylisoquercitrin) is an inhibitor of NADPH oxidase. Quercetin-3-O-glucose-6''-acetate has antioxidant activities.

NADPH NADPH-oxidase ROS

$106

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Triclosan

Irgasan, Cloxifenolum

T13143380-34-5

Triclosan (Irgasan) is an antibacterial and antifungal agent.

Antibacterial Antibiotic Antifungal Apoptosis Autophagy NADPH

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APX-115 free base

Ewha-18278 free base

T103531270084-92-8

APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury.

NADPH NADPH-oxidase

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Prochlorperazine Maleate

Stemetil, Prochlorperazine maleate salt, Compazine, Capazine

T038584-02-6

Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.

Dopamine Receptor NADPH

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