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NADPH

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent. It is used by all forms of cellular life.NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety. This extra phosphate is added by NAD+ kinase and removed by NADP+ phosphatase.

  • Resveratrol
    T1558501-36-0
    Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
    • $36
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  • Casein kinase 1δ-IN-9
    T64376854355-54-7
    Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.
    • $147
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  • Obafistat
    T396352160582-57-8
    Obafistat is a potent inhibitor of aldo-keto reductase AKR1C3 with an IC50 of 1.2 nM for human AKR1C3.
    • $67
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  • GKT136901
    T8408955272-06-7
    GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite
    • $42
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  • Dehydroglyasperin C
    TN3806199331-35-6
    Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases
    • $871
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  • AKR1C3-IN-9
    T67846
    AKR1C3-IN-9 is a selective Aldo-keto Reductase 1C3 (AKR1C3) inhibitor (IC50= 8.92 nM). AKR1C3-IN-9 can significantly reverse the Doxorubicin (DOX) resistance in a resistant breast cancer cell line.
    • $64
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  • Nucleocidin
    T1636124751-69-7
    Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.
    • $1,520
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  • S29434
    T7149874484-20-5
    S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).
    • $51
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  • Quercetin-3-O-glucose-6''-acetate
    TN212654542-51-7
    Quercetin-3-O-glucose-6''-acetate (6 -O-Acetylisoquercitrin) is an inhibitor of NADPH oxidase. Quercetin-3-O-glucose-6''-acetate has antioxidant activities.
    • $106
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  • AKR1C3-IN-4
    T386841284180-11-5
    AKR1C3-IN-4 is a potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3) with an IC50 of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research.
    • $66
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  • Acetohexamide
    T0816968-81-0
    Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.
    • $29
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  • APX-115 free base
    T103531270084-92-8
    APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
    • $51
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  • AKR1C1-IN-1
    T141514906-68-7
    AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).
    • $44
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  • HTS07545
    T61316118666-03-8
    HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM).HTS07545 reduces the rate of hydrogen sulfide (H2S) decomposition.HTS07545 has been used in heart failure studies.
    • $38
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  • AKR1C3-IN-1
    T7406327092-81-9
    AKR1C3-IN-1 is a potent and selective inhibitor of AKR1C3(IC50 of 13 nM).
    • $51
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  • Diphenyleneiodonium chloride
    T71914673-26-1
    Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
    • $38
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  • GLX351322
    T8107835598-94-2
    GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
    • $42
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  • GSK2194069
    T154291332331-08-4
    GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer cells through the action of acetoacetyl-coenzyme A and NADPH.
    • $149
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  • NQO1 substrate
    T137992304503-05-5
    NQO1 substrate is a highly potent NQO1 substrate with potential antitumor activity for leukemia research.
    • $38
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  • Pasiniazid
    T04412066-89-9
    Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
    • $42
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  • Carvedilol phosphate hemihydrate
    T0342610309-89-2
    Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
    • $31
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  • 2-HBA
    T7374131359-24-5
    2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
    • $62
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  • ASP-9521
    T45291126084-37-4
    ASP-9521 is an effective, specific and orally available AKR1C3 inhibitor (IC50: 11 nM, for human).
    • $39
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  • Triclosan
    T13143380-34-5
    Triclosan (Irgasan) is an antibacterial and antifungal agent.
    • $41
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  • Apocynin
    T6391498-02-2
    Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).
    • $50
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  • Metronidazole
    T1079443-48-1
    Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
    • $30
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  • Carvedilol
    T044772956-09-3
    Carvedilol (SKF 105517) Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. The S enantiomer of carvedilol nonselectively binds to and blocks beta-adrenergic receptors, thereby exerting negative inotropic and chronotropic effects, and leading to a reduction in cardiac output. In addition, both enantiomers of carvedilol bind to and block alpha 1-adrenergic receptors, thereby causing vasodilation and reducing peripheral vascular resistance.
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    • Setanaxib
      T60991218942-37-0
      Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
      • $34
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    • KL1333
      T163421800405-30-4
      KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
      • $140
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    • VAS2870
      T4359722456-31-7
      VAS2870 is an inhibitor of NADPH oxidase (NOX).
      • $52
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    • S19-1035
      T67950
      S19-1035 is a potent and specific inhibitor of aldo-keto reductase 1C3 (AKR1C3), displaying an inhibitory concentration (IC50) of 3.04 nM. It is primarily utilized in tumor research.
      • $55
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    • Dicoumarol
      T080966-76-2
      Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.
      • $41
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    • GSK2795039
      T154331415925-18-6
      GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
      • $67
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