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HMG-CoA Reductase

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, ; NADPH-dependent,) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, which is considered, by those who accept the standard lipid hypothesis, an important determinant of atherosclerosis. This enzyme is thus the target of the widely available cholesterol-lowering drugs known collectively as the statins.HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol. More recent evidence shows it to contain eight transmembrane domains.
Cat. No. Product name CAS No. Purity Chemical Structure
T26644 Apomine 126411-13-0 98%
Apomine is an inhibitor of HMG-CoA-reductase. Apomine promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomin...
T11572 HMG499 2416941-68-7 98%
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cho...
T10767 Cerivastatin sodium 143201-11-0 98%
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the prol...
T10070 2'-Ethyl Simvastatin 79902-42-4 98%
2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
TN1438 Beta-Amyrin acetate 1616-93-9 98%
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, ...
T10324 Anhydrosimvastatin 210980-68-0
Anhydrosimvastatin is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.
T1664 Meglutol 503-49-1
Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic st...
T0683 Mevastatin 73573-88-3 97.96%
Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials....
TN1733 Hesperetin 7-O-glucoside 31712-49-9 98.1%
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition...
T1510 Rosuvastatin calcium 147098-20-2 98.85%
Rosuvastatin, a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
T0672 Pravastatin sodium 81131-70-6 99.08%
Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T1487 Fluvastatin sodium 93957-55-2 99.46%
Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
T3698 Alpha-Asarone 2883-98-9 99.59%
Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
T2534 Pitavastatin calcium 147526-32-7 99.71%
Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and hum...
T1207 Lovastatin 75330-75-5 99.72%
Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
T1676 Rosuvastatin 287714-41-4 99.75%
Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversio...
T4717 25-Hydroxycholesterol 2140-46-7 99.78%
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase ...
T6450 Clinofibrate 30299-08-2 99.84%
Clinofibrate(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol an...
T3116 Atorvastatin hemicalcium salt 134523-03-8 99.89%
Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
T0687 Simvastatin 79902-63-9 99.95%
Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
Apomine
T26644
Apomine is an inhibitor of HMG-CoA-reductase. Apomine promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomin...
HMG499
T11572
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cho...
Cerivastatin sodium
T10767
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the prol...
2'-Ethyl Simvastatin
T10070
2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
beta-Amyrin acetate
TN1438
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, ...
Anhydrosimvastatin
T10324
Anhydrosimvastatin is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.
Meglutol
T1664
Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic st...
Mevastatin
T0683
Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials....
Hesperetin 7-O-glucoside
TN1733
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition...
Rosuvastatin calcium
T1510
Rosuvastatin, a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
Pravastatin sodium
T0672
Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
Fluvastatin sodium
T1487
Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
alpha-Asarone
T3698
Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
Pitavastatin calcium
T2534
Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and hum...
Lovastatin
T1207
Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
Rosuvastatin
T1676
Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversio...
25-Hydroxycholesterol
T4717
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase ...
Clinofibrate
T6450
Clinofibrate(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol an...
Atorvastatin hemicalcium salt
T3116
Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
Simvastatin
T0687
Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
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