HMG-CoA Reductase

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, ; NADPH-dependent,) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, which is considered, by those who accept the standard lipid hypothesis, an important determinant of atherosclerosis. This enzyme is thus the target of the widely available cholesterol-lowering drugs known collectively as the statins.HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol. More recent evidence shows it to contain eight transmembrane domains.

Cat. No.	Product name	CAS No.	Purity
T10767	Cerivastatin sodium	143201-11-0	98%
T10767	Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the prol...
T10070	2'-Ethyl Simvastatin	79902-42-4	98%
T10070	2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
T11572	HMG499	2416941-68-7	98%
T11572	HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 μM. HMG499 can eliminate statins-induced accumulation of HMGCR, lower serum ch...
T6994	SR12813	126411-39-0	99.95%
T6994	SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.
T0687	Simvastatin	79902-63-9	99.95%
T0687	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cho...
T3116	Atorvastatin hemicalcium salt	134523-03-8	99.89%
T3116	Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
T6450	Clinofibrate	30299-08-2	99.84%
T6450	Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cho...
T20887	Atorvastatin Sodium	134523-01-6	99.79%
T20887	Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocy...
TN1438	Beta-Amyrin acetate	1616-93-9	99.74%
TN1438	beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, ...
T1664	Meglutol	503-49-1	99.73%
T1664	Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by...
T2534	Pitavastatin calcium	147526-32-7	99.71%
T2534	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol i...
T20765	Atorvastatin	134523-00-5	99.69%
T20765	Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accele...
T24865	Tenivastatin	121009-77-6	99.68%
T24865	Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor that inhibits the production of reactive oxygen species (ROS) and can be us...
T3698	Alpha-Asarone	2883-98-9	99.59%
T3698	alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.
T1207	Lovastatin	75330-75-5	99.59%
T1207	Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
T13131	Tert-Buthyl Pitavastatin	586966-54-3	99.57%
T13131	tert-Buthyl Pitavastatin is Pitavastatin metabolite. Pitavastatin is a potent inhibitor of HMG-CoA reductase.
T1487	Fluvastatin sodium	93957-55-2	99.46%
T1487	Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lower...
T0672	Pravastatin sodium	81131-70-6	99.08%
T0672	Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T12092	Monacolin J	79952-42-4	98.87%
T12092	Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.
T1510	Rosuvastatin calcium	147098-20-2	98.85%
T1510	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activit...