HMG-CoA Reductase

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, ; NADPH-dependent,) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, which is considered, by those who accept the standard lipid hypothesis, an important determinant of atherosclerosis. This enzyme is thus the target of the widely available cholesterol-lowering drugs known collectively as the statins.HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol. More recent evidence shows it to contain eight transmembrane domains.

Cat. No.	Product name	CAS No.	Purity
T26644	Apomine	126411-13-0	98%
T26644	Apomine is an inhibitor of HMG-CoA-reductase. Apomine promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomin...
T11572	HMG499	2416941-68-7	98%
T11572	HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cho...
T10767	Cerivastatin sodium	143201-11-0	98%
T10767	Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the prol...
T10070	2'-Ethyl Simvastatin	79902-42-4	98%
T10070	2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
TN1438	Beta-Amyrin acetate	1616-93-9	98%
TN1438	beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, ...
T10324	Anhydrosimvastatin	210980-68-0
T10324	Anhydrosimvastatin is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.
T1664	Meglutol	503-49-1
T1664	Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic st...
T0683	Mevastatin	73573-88-3	97.96%
T0683	Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials....
TN1733	Hesperetin 7-O-glucoside	31712-49-9	98.1%
TN1733	Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition...
T1510	Rosuvastatin calcium	147098-20-2	98.85%
T1510	Rosuvastatin, a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
T0672	Pravastatin sodium	81131-70-6	99.08%
T0672	Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T1487	Fluvastatin sodium	93957-55-2	99.46%
T1487	Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
T3698	Alpha-Asarone	2883-98-9	99.59%
T3698	Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
T2534	Pitavastatin calcium	147526-32-7	99.71%
T2534	Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and hum...
T1207	Lovastatin	75330-75-5	99.72%
T1207	Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
T1676	Rosuvastatin	287714-41-4	99.75%
T1676	Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversio...
T4717	25-Hydroxycholesterol	2140-46-7	99.78%
T4717	25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase ...
T6450	Clinofibrate	30299-08-2	99.84%
T6450	Clinofibrate（IC50 of 0.47 mM）, a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol an...
T3116	Atorvastatin hemicalcium salt	134523-03-8	99.89%
T3116	Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
T0687	Simvastatin	79902-63-9	99.95%
T0687	Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.