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FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.
Cat. No. Product name CAS No. Purity Chemical Structure
T10870L CP-547632 252003-65-9 98%
CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
T37426 FIIN-1 1256152-35-8 98%
FIIN-1 is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FII...
T27319 FIIN-4 2093088-81-2 98%
FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.
T16364 Infigratinib phosphate 1310746-10-1 98%
Infigratinib phosphate is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
T3512 S49076 HCl 1265966-31-1 98%
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
T16781 Rogaratinib 1443530-05-9 98%
Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
T10870 CP-547632 hydrochloride 252003-71-7 98%
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
T13003 SSR128129E free acid 848463-13-8 98%
SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
T11280 FGFR4-IN-4 2230973-67-6 98%
FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
T6193 Dovitinib Dilactic Acid 852433-84-2 98%
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T8525 EGFR-IN-16 133550-22-8 98%
AG473 is an inhibitor of EGFR in human A431 cells.
T3492 PD-166866 192705-79-6 98%
PD166866 is a selective FGFR tyrosine kinase inhibitor.
TQ0228 Derazantinib 1234356-69-4 98%
Derazantinib (ARQ-087) is an ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocytes (IC50s: 4.5 nM/1.8 nM/...
T2857 2,5-Dihydroxybenzoic acid 490-79-9 98%
Gentisic acid is an active metabolite of salicylic acid degradation with a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and an...
T2609 Masitinib 790299-79-5 98%
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T2446 KI8751 228559-41-9 98%
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
T2341 KW-2449 1000669-72-6 98%
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
T6124 Mubritinib 366017-09-6 98%
Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.
T5473 ASP5878 1453208-66-6 98%
ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.
T2638 Gandotinib 1229236-86-5 98%
LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3....
CP-547632
T10870L
CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
FIIN-1
T37426
FIIN-1 is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FII...
FIIN-4
T27319
FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.
Infigratinib phosphate
T16364
Infigratinib phosphate is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
S49076 HCl
T3512
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
Rogaratinib
T16781
Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
CP-547632 hydrochloride
T10870
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
SSR128129E free acid
T13003
SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
FGFR4-IN-4
T11280
FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
Dovitinib Dilactic Acid
T6193
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
EGFR-IN-16
T8525
AG473 is an inhibitor of EGFR in human A431 cells.
PD-166866
T3492
PD166866 is a selective FGFR tyrosine kinase inhibitor.
Derazantinib
TQ0228
Derazantinib (ARQ-087) is an ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocytes (IC50s: 4.5 nM/1.8 nM/...
2,5-Dihydroxybenzoic acid
T2857
Gentisic acid is an active metabolite of salicylic acid degradation with a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and an...
Masitinib
T2609
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
KI8751
T2446
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
KW-2449
T2341
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
Mubritinib
T6124
Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.
ASP5878
T5473
ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.
Gandotinib
T2638
LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3....
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