T10870L |
CP-547632
|
252003-65-9
|
98%
|
|
CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
|
T37426 |
FIIN-1
|
1256152-35-8
|
98%
|
|
FIIN-1 is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FII...
|
T27319 |
FIIN-4
|
2093088-81-2
|
98%
|
|
FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.
|
T16364 |
Infigratinib phosphate
|
1310746-10-1
|
98%
|
|
Infigratinib phosphate is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
|
T3512 |
S49076 HCl
|
1265966-31-1
|
98%
|
|
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
|
T16781 |
Rogaratinib
|
1443530-05-9
|
98%
|
|
Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
|
T10870 |
CP-547632 hydrochloride
|
252003-71-7
|
98%
|
|
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
|
T13003 |
SSR128129E free acid
|
848463-13-8
|
98%
|
|
SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
|
T11280 |
FGFR4-IN-4
|
2230973-67-6
|
98%
|
|
FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
|
T6193 |
Dovitinib Dilactic Acid
|
852433-84-2
|
98%
|
|
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
|
T8525 |
EGFR-IN-16
|
133550-22-8
|
98%
|
|
AG473 is an inhibitor of EGFR in human A431 cells.
|
T3492 |
PD-166866
|
192705-79-6
|
98%
|
|
PD166866 is a selective FGFR tyrosine kinase inhibitor.
|
TQ0228 |
Derazantinib
|
1234356-69-4
|
98%
|
|
Derazantinib (ARQ-087) is an ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocytes (IC50s: 4.5 nM/1.8 nM/...
|
T2857 |
2,5-Dihydroxybenzoic acid
|
490-79-9
|
98%
|
|
Gentisic acid is an active metabolite of salicylic acid degradation with a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and an...
|
T2609 |
Masitinib
|
790299-79-5
|
98%
|
|
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
|
T2446 |
KI8751
|
228559-41-9
|
98%
|
|
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
|
T2341 |
KW-2449
|
1000669-72-6
|
98%
|
|
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
|
T6124 |
Mubritinib
|
366017-09-6
|
98%
|
|
Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.
|
T5473 |
ASP5878
|
1453208-66-6
|
98%
|
|
ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.
|
T2638 |
Gandotinib
|
1229236-86-5
|
98%
|
|
LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3....
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