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FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.
Cat. No. Product name CAS No. Purity Chemical Structure
T3512 S49076 HCl 1265966-31-1 98%
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
T6036 Brivanib 649735-46-6 98%
Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
T10870 CP-547632 hydrochloride 252003-71-7 98%
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
T1991 ZM323881 hydrochloride 193000-39-4 98%
ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
T11280 FGFR4-IN-4 2230973-67-6 98%
FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
T13003 SSR128129E free acid 848463-13-8 98%
SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
T6193 Dovitinib Dilactic Acid 852433-84-2 98%
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T35331 Dovitinib (TKI258) Lactate 98%
T6132 ENMD-2076 Tartrate 1291074-87-7 98%
ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more select...
T16781 Rogaratinib 1443530-05-9 98%
Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
T10870L CP-547632 252003-65-9 98%
CP-547632 is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50s: 11 nM and 9 nM) with antitum...
T8525 EGFR-IN-16 133550-22-8 98%
AG473 is an inhibitor of EGFR in human A431 cells.
T2372L Ponatinib Hydrochloride 1114544-31-8 98%
Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
T16364 Infigratinib phosphate 1310746-10-1 98%
Infigratinib phosphate is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
T13156L TG 100572 Hydrochloride 867331-64-4 98%
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
T6154 SU11274 658084-23-2
SU11274(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
T19355 Heparan Sulfate 9050-30-0
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
T1338 Sucralfate 54182-58-0
Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.
T7104 Dovitinib lactate 692737-80-7 100%
Dovitinib lactate(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
T2S0007 Ferulic acid sodium 24276-84-4 100%
Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
S49076 HCl
T3512
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
Brivanib
T6036
Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
CP-547632 hydrochloride
T10870
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
ZM323881 hydrochloride
T1991
ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
FGFR4-IN-4
T11280
FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
SSR128129E free acid
T13003
SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
Dovitinib Dilactic Acid
T6193
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
Dovitinib (TKI258) Lactate
T35331
ENMD-2076 Tartrate
T6132
ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more select...
Rogaratinib
T16781
Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
CP-547632
T10870L
CP-547632 is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50s: 11 nM and 9 nM) with antitum...
EGFR-IN-16
T8525
AG473 is an inhibitor of EGFR in human A431 cells.
Ponatinib Hydrochloride
T2372L
Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
Infigratinib phosphate
T16364
Infigratinib phosphate is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
TG 100572 Hydrochloride
T13156L
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
SU11274
T6154
SU11274(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
Heparan Sulfate
T19355
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
Sucralfate
T1338
Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.
Dovitinib lactate
T7104
Dovitinib lactate(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
Ferulic acid sodium
T2S0007
Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
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