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FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.
Cat. No. Product name CAS No. Purity Chemical Structure
T8525 EGFR-IN-16 133550-22-8 98%
AG473 is an inhibitor of EGFR in human A431 cells.
T3512 S49076 HCl 1265966-31-1 98%
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
T6193 Dovitinib Dilactic Acid 852433-84-2 98%
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T11280 FGFR4-IN-4 2230973-67-6 98%
FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
T13003 SSR128129E free acid 848463-13-8 98%
SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
T10870 CP-547632 hydrochloride 252003-71-7 98%
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
T35331 Dovitinib (TKI258) Lactate 98%
T16781 Rogaratinib 1443530-05-9 98%
Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
T6036 Brivanib 649735-46-6 98%
Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
T13156L TG 100572 Hydrochloride 867331-64-4 98%
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
T1338 Sucralfate 54182-58-0 98%
Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.
T19355 Heparan Sulfate 9050-30-0 98%
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
T9030 SU4984 186610-89-9 98%
SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
T1991 ZM323881 hydrochloride 193000-39-4 98%
ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
T2372L Ponatinib Hydrochloride 1114544-31-8 98%
Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
T27319 FIIN-4 2093088-81-2 98%
FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.
T2S0007 Ferulic acid sodium 24276-84-4 98%
Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
T15185 Lucitanib 1058137-23-7 98%
Lucitanib is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, ...
T8976 PD-089828 179343-17-0 98%
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitiv...
T3274 S49076 1265965-22-7 98%
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.
EGFR-IN-16
T8525
AG473 is an inhibitor of EGFR in human A431 cells.
S49076 HCl
T3512
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
Dovitinib Dilactic Acid
T6193
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
FGFR4-IN-4
T11280
FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
SSR128129E free acid
T13003
SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
CP-547632 hydrochloride
T10870
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
Dovitinib (TKI258) Lactate
T35331
Rogaratinib
T16781
Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
Brivanib
T6036
Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
TG 100572 Hydrochloride
T13156L
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
Sucralfate
T1338
Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.
Heparan Sulfate
T19355
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
SU4984
T9030
SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
ZM323881 hydrochloride
T1991
ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
Ponatinib Hydrochloride
T2372L
Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
FIIN-4
T27319
FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.
Ferulic acid sodium
T2S0007
Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
Lucitanib
T15185
Lucitanib is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, ...
PD-089828
T8976
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitiv...
S49076
T3274
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.
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