FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Cat. No.	Product name	CAS No.	Purity
T10870L	CP-547632	252003-65-9	98%
T10870L	CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
T37426	FIIN-1	1256152-35-8	98%
T37426	FIIN-1 is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FII...
T27319	FIIN-4	2093088-81-2	98%
T27319	FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.
T16364	Infigratinib phosphate	1310746-10-1	98%
T16364	Infigratinib phosphate is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
T3512	S49076 HCl	1265966-31-1	98%
T3512	S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
T16781	Rogaratinib	1443530-05-9	98%
T16781	Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
T10870	CP-547632 hydrochloride	252003-71-7	98%
T10870	CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
T13003	SSR128129E free acid	848463-13-8	98%
T13003	SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
T11280	FGFR4-IN-4	2230973-67-6	98%
T11280	FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
T6193	Dovitinib Dilactic Acid	852433-84-2	98%
T6193	Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T8525	EGFR-IN-16	133550-22-8	98%
T8525	AG473 is an inhibitor of EGFR in human A431 cells.
T3492	PD-166866	192705-79-6	98%
T3492	PD166866 is a selective FGFR tyrosine kinase inhibitor.
TQ0228	Derazantinib	1234356-69-4	98%
TQ0228	Derazantinib (ARQ-087) is an ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocytes (IC50s: 4.5 nM/1.8 nM/...
T2857	2,5-Dihydroxybenzoic acid	490-79-9	98%
T2857	Gentisic acid is an active metabolite of salicylic acid degradation with a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and an...
T2609	Masitinib	790299-79-5	98%
T2609	Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T2446	KI8751	228559-41-9	98%
T2446	KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
T2341	KW-2449	1000669-72-6	98%
T2341	KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
T6124	Mubritinib	366017-09-6	98%
T6124	Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.
T5473	ASP5878	1453208-66-6	98%
T5473	ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.
T2638	Gandotinib	1229236-86-5	98%
T2638	LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3....