FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Cat. No.	Product name	CAS No.	Purity
T8525	EGFR-IN-16	133550-22-8	98%
T8525	AG473 is an inhibitor of EGFR in human A431 cells.
T3512	S49076 HCl	1265966-31-1	98%
T3512	S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
T6193	Dovitinib Dilactic Acid	852433-84-2	98%
T6193	Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T11280	FGFR4-IN-4	2230973-67-6	98%
T11280	FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
T13003	SSR128129E free acid	848463-13-8	98%
T13003	SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
T10870	CP-547632 hydrochloride	252003-71-7	98%
T10870	CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficac...
T35331	Dovitinib (TKI258) Lactate		98%
T35331
T16781	Rogaratinib	1443530-05-9	98%
T16781	Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1...
T6036	Brivanib	649735-46-6	98%
T6036	Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.
T13156L	TG 100572 Hydrochloride	867331-64-4	98%
T13156L	TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
T1338	Sucralfate	54182-58-0	98%
T1338	Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.
T19355	Heparan Sulfate	9050-30-0	98%
T19355	Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
T9030	SU4984	186610-89-9	98%
T9030	SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
T1991	ZM323881 hydrochloride	193000-39-4	98%
T1991	ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
T2372L	Ponatinib Hydrochloride	1114544-31-8	98%
T2372L	Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
T27319	FIIN-4	2093088-81-2	98%
T27319	FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.
T2S0007	Ferulic acid sodium	24276-84-4	98%
T2S0007	Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
T15185	Lucitanib	1058137-23-7	98%
T15185	Lucitanib is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, ...
T8976	PD-089828	179343-17-0	98%
T8976	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitiv...
T3274	S49076	1265965-22-7	98%
T3274	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.