T15815 |
LY3295668
|
1919888-06-4
|
98%
|
|
LY3295668 is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.
|
T10412 |
Aurora inhibitor 1
|
2227019-45-4
|
98%
|
|
Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).
|
T11958 |
MBM-17
|
2083621-90-1
|
98%
|
|
MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM). It effectively inhibits the proliferation of cancer cells by inducing cell cycle arres...
|
T6936 |
PF-03814735
|
942487-16-3
|
98%
|
|
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
|
T11959 |
MBM-17S
|
2083621-91-2
|
98%
|
|
MBM-17S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-17S shows antitumor activities, and no obvious to...
|
T16862 |
SCH-1473759
|
1094069-99-4
|
98%
|
|
SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).
|
T8537 |
Tripolin A
|
1148118-92-6
|
98%
|
|
Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)
|
T12864 |
SCH-1473759 hydrochloride
|
1094067-13-6
|
98%
|
|
SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).
|
T11638 |
Ilorasertib hydrochloride
|
1847485-91-9
|
98%
|
|
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1...
|
T15829 |
L 888607 Racemate
|
1030017-51-6
|
98%
|
|
L 888607 Racemate is a selective antagonist of prostaglandin D2 receptor subtype 1 (DP1) (Kis: 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respect...
|
T12010 |
Aurora B inhibitor 1
|
937276-52-3
|
98%
|
|
Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor, has a Ki value of <0.010 uM.
|
T14926 |
Centrinone-B
|
1798871-31-4
|
98%
|
|
Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).
|
T23426 |
TC-A 2317 hydrochloride
|
1245907-03-2
|
98%
|
|
TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows ant...
|
T11960 |
MBM-55
|
2083622-09-5
|
98%
|
|
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
|
T2509 |
Tozasertib
|
639089-54-6
|
98%
|
|
MK-0457 is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different kinases.
|
T2617 |
SNS-314 Mesylate
|
1146618-41-8
|
98%
|
|
SNS-314 Mesylate is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.
|
T2341 |
KW-2449
|
1000669-72-6
|
98%
|
|
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R...
|
T2118 |
SC-514
|
354812-17-2
|
98%
|
|
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
|
T3068 |
AT9283
|
896466-04-9
|
98%
|
|
AT9283 is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
|
T2611 |
CCT 137690
|
1095382-05-0
|
98%
|
|
CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).
|