zikv

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Cephaeline hydrochloride, a phenolic alkaloid found in Indian Ipecac, effectively inhibits the infection of viruses ZIKV and EBOV.

Wulfenioidin F, a diterpenoid isolated from the whole plant of Orthosiphon wulfenioides, exhibits anti-Zika virus (ZIKV) activity with an EC50 of 8.07 μM and hinders virus replication by inhibiting the expression of the ZIKV envelope (E) protein [1].

Wulfenioidin H (Compound 5), a diterpenoid, demonstrates anti-Zika virus (ZIKV) activity by inhibiting the expression of the ZIKV envelope (E) protein, resulting in an effective concentration ( EC_{50} ) value of 8.50 μM [1].

XA-E, a chemical compound isolated from a methanol-ethyl acetate extract of A. keiskei, exhibits anti-Zika virus (anti-ZIKV) activity, demonstrated by an inhibitory concentration 50% (IC50) value of 22.0 µM [1].