zikv

ZIKV-IN-1 is a potent inhibitor of Zika virus (EC50: 2.8 μM, EC90: 6.8 μM) with anti-ZIKV effects and low cytotoxicity, showing high affinity for the RdRp domain of ZIKV.

ZIKV-IN-4 is a low cytotoxic, acid-stable anti-ZIKV agent with an EC50 value of 3.49 μM. ZIKV-IN-4 exhibited potent inhibition of ZIKV NS5 MTase.

ZIKV-IN-2 is a potent inhibitor of ZIKV NS5 methyltransferase (MTase) (IC50: 38.86 μM) and inhibits the replication and infection of ZIKV, which can be used to study Zika virus (ZIKV).

ZIKV-IN-5 is an acid-stable, low cytotoxic anti-ZIKV agent with an EC50 value of 0.71 μM. ZIKV-IN-5 showed effective inhibition of ZIKV NS5 MTase activity.

ZIKV-IN-K22 is a potent antiviral agent against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibiting ZIKV with IC50 of 2.1 μM.

ZIKV-IN-3, a derivative of andrographolide, serves as a potent inhibitor of the Zika virus (ZIKV) NS5 methyl transferase (MTase), showcasing an IC50 of 18.34 μM. It effectively curtails ZIKV replication and infection, making it valuable in Zika virus research.

ZIKV-IN-6 (compound 22) is a direct inhibitor of the Zika virus (ZIKV) that binds to its RNA-dependent RNA polymerase (RdRp), obstructing viral RNA synthesis mediated by the ZIKV NS5 protein. The compound exhibits low cytotoxicity (CC50 >50 μM) and mitigates excessive inflammatory response and pyroptosis [1].

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Azaribine (2;,3;,5;-Tri-O-acetyl-6-azauridine) is an orotate monophosphate decarboxylase (OMPD) inhibitor with broad-spectrum antiviral activity, inhibiting viral genome replication and gene transcription.Azaribine has been used in the study of Zika virus (ZIKV) infections, and in the study of psoriasis, arthritis and mycosis fungoides. Azaribine is used to study Zika virus (ZIKV) infections, psoriasis and mycosis fungoides.

LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor with antiviral activity for the study of ZIKV virus.

T-1105 is a broad-spectrum antiviral inhibitor.

ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1].

SN 2 is a novel and potent TRPML3 ion channel activator(EC50 of 1.8±0.13 μM).

p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].

Cephaeline hydrochloride, a phenolic alkaloid found in Indian Ipecac, effectively inhibits the infection of viruses ZIKV and EBOV.

Compound 34e (NS2B NS3-IN-4) is an allosteric inhibitor of the DENV2 and ZIKV NS2B NS3 proteases, exhibiting IC50 values of 0.69 µM for DENV2 and 1.04 µM for ZIKV NS2B NS3 proteases [1].

NS2B NS3-IN-5 (Compound 25b) is a variant of the DENV2 and ZIKV NS2B NS3 protease inhibitor with IC50 values of 0.67 μM for ZIKV and 4.38 μM for DENV2.

NS2B NS3-IN-6 (Compound 1a) is a derivative of the DENV and ZIKV NS2B NS3 protease inhibitor, exhibiting IC50 values of 2.23 μM for the ZIKV NS2B NS3 protease and 25.2 μM for the DENV NS2B NS3 protease.

CYP2C19-IN-1 is a potent, non-genotoxic, non-hepatotoxic inhibitor of CYP2C19. CYP2C19-IN-1 inhibits RNA-dependent RNA polymerase (RdRP) (Ki: 6.16 μM) and can be used to study Zika virus (ZIKV) infection.

CYP2C1 CYP2C19-IN-2 is a potent inhibitor of CYP2C9 CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.

CYP2C9 CYP2C19-IN-1 is a potent inhibitor of CYP2C9 CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.

cn-716 is a novel Zika virus (ZIKV) NS2B-NS3pro protease inhibitor.

NS2B NS3-IN-7 is a highly potent inhibitor of the Zika virus NS2B-NS3 protease, possessing a Ki value of 2.33 nM. It effectively reduces the number of ZIKV-infected cells.

LabMol-301, a chemical compound, effectively inhibits NS5 RdRp and NS2B-NS3pro activity with IC50 values of 0.8 μM and 7.4 μM, respectively. Additionally, it exhibits cytoprotective effects, safeguarding against Zika virus (ZIKV)-induced cell death.