vldl

Imanixil (HOE-402 free base) is an LDL receptor (LDLR) inducer, a hypolipidemic and hypocholesterolemic compound with antiatherogenic activity that inhibits the production of very low-density lipoproteins (VLDLs).Imanixil acts by stimulating the LDL receptor pathway.

Taurine (2-Aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues and is one of the constituents of bile acids. Taurine is involved in a number of processes related to energy expenditure and muscle function, and can treat fatigue and muscles as well as improve immune function.

Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor designed to reduce the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. It failed in phase III trials due to an excess of deaths.

Anti-Mouse/Rat/Bovine VLDL-R Antibody (IgG-6A6) is a murine-derived IgG1, λ antibody inhibitor targeting VLDL-R in mice, rats, and bovines.

Antiflammin P2 is a nonapeptide fragment of lipocortin I which has no phospholipase A2 inhibitory and anti-inflammatory activity.

Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Triarachidin (1,2,3-Trieicosanoyl Glycerol) is a triarachidic acid triglyceride. Triglycerides (TGs) are also known as triacylglycerols or triacylglycerides. TGs are the main constituent of vegetable oil and animal fats. TGs are major components of very low density lipoprotein (VLDL) and chylomicrons, play an important role in metabolism as energy sources and transporters of dietary fat. They contain more than twice the energy (9 kcal/g) of carbohydrates and proteins.

Melinamide is an antilipidemic compound with pharmacological properties similar to gemfibrozil. Melinamide reduces elevated serum lipids primarily by lowering the triglyceride-rich very low-density lipoprotein (VLDL) fraction. In Type III hyperlipoproteinemia, where cholesterol elevation arises from intermediate-density lipoproteins (IDL), melinamide can decrease serum cholesterol levels.

Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL thereby, producing an increase in serum HDL-cholesterol levels and a decrease in serum LDL-cholesterol levels.

CI 924 is a lipid-lowering drug. CI 924 increased anti-atherosclerotic HDL and decreased VLDL at 600 mg/day.

GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.

F81-1144b is a matrix metalloproteinase inhibitor which reduces secretion of very low density lipoprotein-triacylglycerol, thereby lowering TAG levels in serum and the liver. F81-1144b also lowers VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose.

Gemfibrozil (Standard) is the standard substance of Gemfibrozil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Triarachidin (Standard) is the standard substance of Triarachidin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triarachidin (1,2,3-Trieicosanoyl Glycerol) is a triarachidic acid triglyceride. Triglycerides (TGs) are also known as triacylglycerols or triacylglycerides. TGs are the main constituent of vegetable oil and animal fats. TGs are major components of very low density lipoprotein (VLDL) and chylomicrons, play an important role in metabolism as energy sources and transporters of dietary fat. They contain more than twice the energy (9 kcal/g) of carbohydrates and proteins.

Stachybotramide preferentially stimulate the plasma cholesteryl ester transfer protein (CETP)-mediated transfer of cholesteryl esters (CE) from high density lipoprotein (HDL) to both very low density lipoprotein (VLDL) and low density lipoprotein (LDL).

LipoproteinLipase, Burkholderia sp. (EC 3.1.1.34), is a member of the lipase gene family and functions as a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acid molecules and one monoacylglycerol molecule. It plays a role in aiding the uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids by cells. Lipoprotein requires ApoC-II as a cofactor and is attached to the luminal surface of capillary endothelial cells through glycosylphosphatidylinositol high-density lipoprotein-binding protein 1 (GPIHBP1) and heparan sulfate proteoglycans.

Lipoprotein Lipase, Bovine (EC 3.1.1.34), is a member of the lipase gene family and functions as a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as chylomicrons and very-low-density lipoproteins (VLDL), into two free fatty acid molecules and one monoacylglycerol molecule. It also facilitates the uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids by cells. The enzyme requires ApoC-II as a cofactor and is attached to the luminal surface of capillary endothelial cells via glycosylphosphatidylinositol (GPI) high-density lipoprotein-binding protein 1 (GPIHBP1) and heparan sulfate proteoglycans.