uridine 5'-triphosphate

Uridine triphosphate trisodium salt (UTP, Trisodium Salt) is a nucleotide.

Uridine triphosphate (Uridine 5'-triphosphate) increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor.

Uridine triphosphate (UTP) is a purine nucleotide P2U receptor agonist with potential use in lung cancer treatment. By activating P2Y2 receptors, it enhances the proliferation of human cancerous ductal epithelial cells. Additionally, UTP induces fibrotic responses in cardiac fibroblasts through P2Y2 receptor activation and prolongs the action potential duration of guinea pig papillary muscles via the P2Y2 purinergic receptor.

Uridine 5'-triphosphate tris salt is an endogenous metabolite.

Aminoallyl-UTP (5-(3-Aminoallyl)uridine-5'-O-triphosphate) is an amine-modified nucleotide utilized in affinity-tagged UTP synthesis. Its incorporation into complementary RNA (cRNA) and bacterial transfer-messenger RNA (tmRNA) enables the creation of fluorescently labeled probes for microarrays.

Pseudouridine-5'-triphosphate (Pseudo-UTP) is widely known for its role in polymerase-mediated RNA synthesis, frequently surpassing uridine in unmodified mRNAs due to improved nuclease stability, immunogenicity, and translational properties.

2'-O-Methyl-5-methyluridine 5'-triphosphate (triethylammonium), a thymidine analog, exhibits insertional activity in replicated DNA, enabling its application in labeling cells and monitoring DNA synthesis [1].

5-Methoxyuridine 5'-triphosphate trisodium solution (100mM) is a modified nucleotide triphosphate (NTP). It can be incorporated into mRNA using T7 RNA polymerase.

N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide. It is utilized in the synthesis of mRNA to decrease immunogenicity and enhance stability [1].

2'-O-Methyl-5-methyluridine 5'-triphosphate triethylammonium salt is a Nucleoside Triphosphate.

Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

Cytidine 5'-diphosphate trisodium salt (CDP) catalyzes the production of Cytidine triphosphate (CTP) for DNA and RNA synthesis by transferring a phosphoryl group from ATP to cytidine monophosphate (CMP) through the action of uridine monophosphate kinase (UMPK).

Uridine-5'-O-(3-thiotriphosphate) tetrasodium (UTPγS) is a stable analog of Uridine triphosphate (UTP) and acts as a potent agonist for P2Y2 and P2Y4 receptors, offering enhanced metabolic stability. It can stimulate the generation of inositol phosphates in 1321N1 astrocytoma cells, which stably express phospholipase C-coupled human P2U purinergic receptors (EC50= 240 nM).

Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled Uridine triphosphate sodium (T8393) that can be used for isotope tracing.Uridine triphosphate (UTP) is a key in RNA synthesis molecule that serves as a substrate for RNA polymerase during transcription.

3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.

Uridine 5′-triphosphate tris salt (Uridine 5'-triphosphoric acid) is an agonist to the P2Y receptor and has been used to study concentrations of intracellular Ca2+, as well as a phosphate donor for in vitro kinase assays.

6-Azauridine triphosphate (6-Azauridine 5′-triphosphate), a nucleotide analog similar to uridine triphosphate, facilitates the study of RNA synthesis mechanisms and transcription regulation [1].

Capecitabine-D11 is a deuterated compound of Capecitabine. Capecitabine (T1408) has a CAS number of 154361-50-9. Capecitabine (T1408) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Uridine triphosphate-15N2 dilithium is the 15N-labeled version of uridine triphosphate. Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a nucleotide that regulates functions related to pancreatic endocrine and exocrine behavior, proliferation, channels, transporters, and intracellular signaling under both normal and pathological conditions.

Capecitabine (Standard) is a reference standard for research and analysis in studies involving Capecitabine. Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Doxifluridine (Standard) is a reference standard for research and analysis in studies involving Doxifluridine. Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

Capecitabine-D11 (Standard) is a reference standard of Capecitabine-D11 intended for quantitative analysis, quality control, and related biochemical research applications. Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

5-Bromo-UTP (5-BrUTP) trisodium is an analog of uridine triphosphate (UTP). As an RNA synthesis precursor, 5-Bromo-UTP trisodium is incorporated into newly synthesized RNA strands during transcription, substituting for some UTP. This compound is useful for labeling newly formed RNA, enabling high-resolution visualization of transcription sites and RNA transport.