urease

Urease is produced by many types of bacteria and is an effective virulence factor for some pathogenic bacteria. Urease is also central to the metabolism and virulence of Helicobacter pylori, helping it colonize the stomach lining [1] .

Urease Inhibitor 07 is an isosubstituted metalloproteinase inhibitor with potential activity against Mycobacterium tuberculosis strain H37Rv.

Butylboronicacid is a competitive inhibitor of urease and acts as a monosaccharide complexing reagent.

Urease-IN-16, with an IC50 of 132 µmol L, is a urease inhibitor that coordinates with nickel atoms through the oxygen atoms of either carbonyl or boronic acid groups. This compound holds significant potential as an additive in the development of efficient fertilizers and medical applications.

Urease-IN-6, a potent Urease inhibitor, exhibits an IC50 value of 14.2 μM and is utilized in the research of peptic and gastric ulcers [1].

Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori), with an IC50 of 0.14 μM for H. pylori inhibition. It effectively decreases apoptosis in GES-1 cells infected with H. pylori and reduces levels of ROS and γH2AX. Urease-IN-20 also demonstrates significant gastric mucosal protective effects, making it suitable for H. pylori research.

Urease-IN-11 (Compound 6e), with an IC50 of 10.41 µM, serves as a competitive inhibitor of urease. This compound is useful in researching diseases like urease-related gastritis and peptic ulcer [1].

Urease-IN-19 (Compound 3c) is a potent inhibitor of urease, demonstrating an IC50 value of 2.7 µM. It shows potential for use in research related to kidney stones and gastric ulcers.

Urease-IN-4 is a potent urease inhibitor, demonstrating an IC50 value of 1.64 µM and exhibiting low cytotoxicity. Additionally, it exhibits inhibitory activity against P. vulgaris, with an IC50 value of 15.27 µg mL.

Urease-IN-7 (Compound 5k) is a competitive inhibitor of the enzyme urease, with an IC50 of 3.33 μM and a K_i of 3.62 μM, offering potential applications in the study of peptic and gastric ulcers [1].

Urease-IN-8 (Compound 5e) is a competitive urease inhibitor with an IC50 of 3.51 μM and a Ki of 3.11 μM, suitable for research on peptic and gastric ulcers [1].

Urease-IN-2 is a non-competitive inhibitor of urease (IC50: 0.94 μM, Ki: 1.6 μM) that non-competitively inhibits Jack bean urease (JBU).

Urease-IN-9 (Compound 1e), an urease inhibitor with an IC50 of 19.5 μM, effectively impedes the enzyme's activity [1].

Urease-IN-18 (compound 13a) is a non-competitive urease inhibitor with an IC50 value of 1.6 μM. Urease plays a role in maintaining an alkaline environment that supports the survival and proliferation of certain pathogens within the host.

Urease-IN-10 (Conjugate 4), a competitive inhibitor of urease, exhibits an IC50 of 3.59±0.07 μM and a Ki of 7.45 μM. This compound is a conjugate of Diclofenac and Sulfanilamide. The combination of Diclofenac-sulfanilamide effectively inhibits Jack bean urease (JBU) through competitive inhibition [1].

Urease-IN-5, an urease inhibitor, exhibits a potent inhibitory effect with an IC50 of 1.473 µM and demonstrates low cytotoxicity alongside inhibitory activity against P. vulgaris, marked by an IC50 of 17.78 µg mL.

Urease -IN-1 is a urease inhibitor (IC50: 2.21±0.45 μM).

Acetohydroxamic acid (N-Hydroxyacetamide) is an antagonist of the bacterial enzyme urease.

4-Hexen-3-one inhibits the growth of H. pylori in the ATCC 43526 strain and TDR strain. Additionally, this compound suppresses urease activity.

9,11-Dehydro-β-boswellic acid is a compound with urease inhibitory activity and acts as an inhibitor of 5-lipoxygenase (5-LO), a critical enzyme in leukotriene biosynthesis.

2-Chlorocinnamic acid is a photosensitive compound, it can inhibit tyrosinase activity. 2-Chlorocinnamic acid and 4-chlorocinnamic acid show potent urease inhibitory activities with the respective IC50 values of 0.66 and 1.10 uM.

MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). It is selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urease, trypsin, α-chymotrypsin, plasmin, and elastase at concentrations up to 4 mM.

4-Chlorocinnamic acid is a photosensitive compound. 2-Chlorocinnamic acid and 4-chlorocinnamic acid show potent urease inhibitory activities with the respective IC50 values of 0.66 and 1.10 uM.

Tolfamide is a benzamide compound and an inhibitor of urease.