taltobulin

Taltobulin (HTI-286) is a synthetic analog of the tripeptide cysteine, a microtubule protein inhibitor that inhibits liver tumor cell proliferation in vitro and tumor growth in vivo.Taltobulin is cytotoxic, induces mitotic arrest and apoptosis, and may be used in the study of breast cancer and microtubule tissue-related diseases.

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

The compound '(6R)-Taltobulin intermediate-9' serves as an intermediate in the synthesis of Taltobulin. Taltobulin is a common cytotoxic component (ADC Cytotoxin) in the preparation of antibody-drug conjugates (ADCs) and acts as a potent inhibitor of microtubule/tubulin. It disrupts tubulin polymerization, induces mitotic arrest, and triggers apoptosis (apoptosis).

Taltobulinintermediate-6 serves as an intermediate in the synthesis of Taltobulin. Taltobulin is a common cytotoxic component in the preparation of antibody-drug conjugates (ADC Cytotoxin) and acts as a potent inhibitor of microtubules/tubulin (Microtubule/Tubulin). It disrupts microtubule polymerization, induces mitotic arrest, and triggers apoptosis (apoptosis).

Taltobulinintermediate-7 is an intermediate in the synthesis of Taltobulin. Taltobulin is a commonly used toxin component in ADC preparation (ADC Cytotoxin) and serves as a potent inhibitor of microtubule/tubulin. It disrupts microtubule polymerization, induces mitotic arrest, and triggers apoptosis [apoptosis].

Taltobulinintermediate-12 serves as an intermediate in the synthesis of Taltobulin. Taltobulin is a commonly used cytotoxin in the preparation of Antibody-Drug Conjugates (ADC) and acts as a potent inhibitor of microtubule/tubulin. It disrupts microtubule polymerization, causing mitotic arrest and inducing apoptosis (apoptosis).

Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, effectively bypasses P-glycoprotein-mediated resistance both in vitro and in vivo as a robust antimicrotubule agent. It prevents the polymerization of purified tubulin, destabilizes cellular microtubule structures, and triggers both mitotic arrest and apoptosis [1].

(R)-Taltobulin ((R)-HTI-286) can be utilized as a reference standard.

Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Taltobulin intermediate-4 is a defined synthetic intermediate used in the multistep preparation of Taltobulin, a highly potent tubulin inhibitor and cytotoxic payload widely employed in antibody–drug conjugate development, where Taltobulin disrupts microtubule polymerization, induces mitotic arrest, and triggers apoptosis in rapidly dividing tumor cells.