t1d

ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).

Volagidemab (AMG-477) is a glucagon receptor (GCGR) antagonist and monoclonal antibody for the study of endocrine and metabolic diseases such as type 1 diabetes (T1D) and hypoglycemia.

BDC2.5 Mimotope 1040-63 is a biologically active peptide used in the investigation of type 1 diabetes (T1D), an autoimmune disease where T cells induce destruction of pancreatic islet β cells. This mimotope, originating from the TCR transgenic model (BDC2.5), facilitates the examination of antigen presentation mechanisms to islet autoantigen-specific T cells, contributing to the understanding of T cell-mediated beta-cell damage due to autoreactive T cell responses.

Temelimab (GNbAC-1) is a monoclonal antibody targeting endogenous retroviruses in humans, used for studying multiple sclerosis (MS) and type 1 diabetes (T1D).

Tregitope 289 is a peptide derived from the Fc region of immunoglobulin G (IgG) and serves as a highly conserved T cell epitope that promotes the expansion of natural regulatory T cells. When co-delivered with type 1 diabetes (T1D) antigens, it can delay the onset of hyperglycemia and reduce the incidence of diabetes in NOD mouse models. Tregitope 289 is applicable for research in T1D and other autoimmune diseases.