sulfated

Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced byH. medicinalis.1It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC50value of 3.7 μM.2 1.Niehrs, C., Huttner, W.B., Carvallo, D., et al.Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferasesJ. Biol. Chem.265(16)9314-9318(1990) 2.Payne, M.H., Krstenansky, J.L., Yates, M.T., et al.Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptidesJ. Med. Chem.34(3)1184-1187(1991)

CCK (26-30) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-30) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 10% when used at a concentration of 0.1 mM.

CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.

CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-31) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 21% when used at a concentration of 0.1 mM.

CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 uM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 uM), an effect that can be reversed by naloxone. Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in mice when administered at doses up to 1 uMol/kg.

Acetyl-Hirudin (54-65) (sulfated) directly binds to thrombin-rHCII(L444R), obstructing the interaction between the N-terminal acidic domain of rHCII and the anion-binding exosite I of thrombin, thereby stabilizing the complex.

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide with greater thrombin affinity than Hirugen, exhibiting a dissociation constant (K D) of less than 100 nM. This compound acts as an antithrombotic agent, effectively inhibiting thrombin-induced fibrin clot formation with an inhibitory concentration (IC 50) of 0.087 μM [1].

CCK Octapeptide, non-sulfated acetate is a synthetic desulfated peptide of cholecystokinin.

Hirudin (55-65) (sulfated), a fragment of Hirudin, is a thrombin inhibitor with anticoagulant effects and blood anticoagulant properties.

De-N-sulfated heparin sodium salt is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

[Thr28, Nle31]-Cholecystokinin (25-33) is a bioactive peptide analog of Cholecystokinin (CCK) that functions as both a hormone and neurotransmitter in the gastrointestinal and central nervous systems, playing a role in satiation by inhibiting food intake. Compared to native CCK8, this analog displays enhanced stability in acidic environments and resistance to air oxidation, due to the substitution of Methionine with Threonine at position 28 and Norleucine at position 31. Structurally, it features a gamma-turn at Thr4, followed by a Gly5-separated helical region encompassing the C-terminal residues.

Cholecystokinin Octapeptide, desulfated (CCK Octapeptide, non-sulfated) is an octapeptide composed of eight amino acids from cholecystokinin-8.

Cholecystokinin Octapeptide, desulfated TFA, is a synthetic octapeptide derived from Cholecystokinin (CCK) that has undergone desulfation.

Caerulein, desulfated TFA is Caerulein after desulfurization.Caerulein is a deceptide with the same five carboxy-terminating amino acids as gastrin and cholecystatin (CCK)..

Caerulein, desulfated (FI-6934, desulfated) is a desulfated form of Caerulein, a neuropeptide with lower smooth muscle activity, stimulates lipase secretion, and inhibits gastric acid secretion.

Caerulein, desulfated ammonium is desulfated Caerulein formed by hydrolysis of Caerulein, a neuropeptide with low smooth muscle activity that stimulates lipase secretion and inhibits gastric acid secretion.

Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse proteins for numerous important biological activities.Heparin sodium salt (Sodium heparinate) significantly inhibits exosome-cell interactions.

Hirudin is a thrombin inhibitor that improves Gsdmd-mediated pyroptosis by inhibiting irf2. It can be used in research on diabetic nephropathy.

MMAU (GMP) refers to the GMP grade reagents of MMAU. MMAU (β-D-Glucuronylmonomethylauristatin E) is an effective payload. This glycoside-type payload is relatively stable in its unbound, free state. When it is converted to the de-sulfated state through the action of lysosomal enzymes, it will activate the cytotoxicity of the payload.

Bivittoside A is a non-sulfated hexoside analog obtained from Bovine sea cucumber with antifungal activity and potential antitumor activity.

Bivittoside B is a non-sulfated hexoside analog obtained from Bovine sea cucumber with antifungal activity and potential antitumor activity.

Lithocholic acid 3-sulfate disodium (Sulfolithocholic acid disodium) acts as a RORgammat ligand and inhibits Th17 cell differentiation.Lithocholic acid 3-sulfate disodium is a sulfated product of lithocholic acid (LCA) and induces a decrease in arterial blood pressure. Lithocholic acid 3-sulfate disodium is a sulfated product of lithocholic acid (LCA) that induces cellular damage.

3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C.2,3 |1. Norii, T., Yamaga, N., and Yamasaki, K. Metabolism of 7β-hydroxycholesterol-4-14C in rat. Steroids 15(3), 303-326 (1970).|2. Alvelius, G., Hjalmarson, O., Griffiths, W.J., et al. Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick disease, type C. J. Lipid Res. 42(10), 1571-1577 (2001).|3. Maekawa, M., Omura, K., Sekiguchi, S., et al. Identification of two sulfated cholesterol metabolites found in the urine of a patient with Niemann-Pick disease type C as novel candidate diagnostic markers. Mass Spectrom. (Tokyo) 5(2), S0053 (2016).

6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.1It has been used for the chiral separation of nadolol racemates by capillary electrophoresis. 1.Wang, F., Dowling, T., Bicker, G., et al.Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin mediaJ. Sep. Sci.24(5)378-384(2001)