spermatogenesis

inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)

Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders.

Perfluoroenanthic acid (Perfluoroheptanoic acid) is a perfluoroalkyl substance (PFAS) that negatively impacts spermatogenic development and testicular m6A RNA methylation in offspring exposed during gestation, thus impeding spermatogenesis and inducing reproductive toxicity. Additionally, in primary cortical neuron cultures, Perfluoroenanthic acid alters dendritic spine morphology and synaptogenesis, enhances neural activity and synaptic transmission, and increases the expression of excitatory synapse-associated proteins Synaptophysin and PSD95.

Dimethylmyleran can promote Haematological change and affect spermatogenesis.

SC 32855 is a 1,4-benzodiazepine that has been shown to arrest of spermatogenesis and degeneration of the germinal epithelium.

ALDH1A2-IN-1 is an active-site directed, reversible ALDH1A2 inhibitor that prevents spermatogenesis and can be used in male contraceptive research.

H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and or elongation factor 1 alpha, and is an Hsp90 regulator.

Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and or RNA and protein synthesis [1].

ALDH1A1 2-IN-1, an inhibitor of ALDH1A1 and ALDH1A2, can be used to prevent spermatogenesis [1].