sms 2

SMS2-IN-1 is an effective and highly selective sphingomyelin synthetase 2 (SMS2) inhibitor with IC50 of 6.5 nM and Kd of 37 nM. Sms2-in-1 is 150 times more selective to SMS2 than SMS1 (IC50 is 1000 nM).

SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50: 91 nM) used for studying atherosclerosis.

Malabaricone C is a bioactive chemical.

Octreotide (SMS 201-995) is a potent inhibitor of growth hormone, glucagon, and insulin.

Octreotide pamoate is an antineoplastic agent.

Octreotide Acetate (Sandostatin) is a potent, long-acting synthetic somatostatin octapeptide analog that inhibits secretion of growth hormone.

Moexipril ethyl ester is a long-acting, non-sulfhydryl angiotensine-converting enzyme inhibitor.

Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.2This product is a mixture of SMs, with variable fatty acyl chain lengths, isolated from buttermilk. [Matreya, LLC. Catalog No. 1329] 1.Slotte, J.P., and Ramstedt, B.The functional role of sphingomyelin in cell membranesEur. J. Lipid Sci. Technol.109(10)977-981(2007) 2.Shayman, J.A.SphingolipidsKidney Int.58(1)11-26(2000)

2-Myristyldistearin (SMS), a triacylglycerol comprising myristic acid and stearic acid [1], showcases its intricate structural composition.