slf

SLF is a synthetic ligand for FKBP12, which increases Ca2+ efflux and protein synthesis to improve skeletal muscle function, and is used in the study of central nervous system diseases and cancer.

SLF-amido-C2-COOH (ZZY01-083) is an FKBP ligand with potential antimicrobial activity for the synthesis of PROTAC.

KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, also known as a molecular glue, that facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, thus forming KB02-SLF[1] and enhancing the longevity of protein degradation in biological systems.

KB03-SLF is a protease with the capability to target specific proteins and regulate intracellular protein levels by inducing protein degradation. This mechanism renders KB03-SLF potentially valuable in the suppression of related diseases.

10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.

SLF TFA, a synthetic ligand for FK506-binding protein (FKBP), exhibits affinity toward FKBP51 with a value of 3.1 μM and demonstrates an IC50 of 2.6 μM for FKBP12. This compound is utilized in the synthesis of PROTAC [1] [2] [3].

22-SLF is a PROTAC degrader that operates by FBXO22-dependent degradation of FK506 Binding Protein 12 (FKBP12) with a DC50 of 0.5 µM. Additionally, 22-SLF can degrade other endogenous proteins, such as BRD4 and the EML4-ALK fusion protein (EML4-ALK fusion protein).

SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.

SLF1081851 (TFA) is a Spns2 inhibitor with an IC50 value of 1.93 μM for inhibiting S1P release, playing a key role in development and the immune system.

SLF1081851 (hydrochloride), a Spns2 inhibitor, effectively inhibits S1P release with an IC50 value of 1.93 μM. This compound is instrumental in the development and functioning of the immune system [1].

SLF80821178 hydrochloride is an orally active anticancer compound that effectively targets the inhibitory function of Spns2 (sphingosine-1-phosphate transporter) and can significantly reduce the release of sphingosine-1-phosphate (S1P) in HeLa cells. Has an IC50 value of 51 nM. Furthermore, SLF80821178 hydrochloride effectively reduced circulating lymphocyte levels in a mouse model without significant effects on plasma S1P levels.

SLF80821178 is a potent and orally active inhibitor of sphingosine-1-phosphate transporter (Spns2). It inhibits S1P release in HeLa cells with an IC50 of 51 nM and has a half-life of 2.4 hours in mice.

BAY 2666605 is an orally active inhibitor of PDE3A (IC50 = 87 nM) and PDE3B (IC50 = 50 nM) with noted anticancer effects.

dFKBP-1 is a potent PROTAC-based FKBP12 degrader incorporating the FKBP12 ligand SLF, the Thalidomide-based cereblon ligand, and a linker[1].

E3 Ligase Ligand-linker Conjugate 139 is an E3 ubiquitin ligase ligand and linker for PROTACKB03-SLF, used in cancer research.

E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.

KB02-amide-PEG2-C2-acid is a synthetic E3 ligase ligand-linker conjugate (E3 ligase Ligand-linker conjugate) commonly used for the synthesis of PROTACs, such as KB02-SLF.

KB02-COOH is a synthetic fragment derived from ubiquitin E3 ligase ligand KB02, which possesses potential utility in the synthesis of PROTAC compounds. Notably, KB02-COOH can be employed in the generation of PROTAC constructs like KB02-JQ1 and KB02-SLF.

AUTAC2 is an FKBP12-targeting autophagy-mediated degrader that incorporates both an FBnG (p-fluorobenzyl guanine) moiety and an SLF moiety, with SLF binding noncovalently to FKBP12, AUTAC2 is utilized in targeted protein degradation research to explore selective autophagic clearance, intracellular quality control mechanisms, and novel degrader design strategies.

TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the substantial inhibition of FKBP12 in HeLa cells [1].

HO-CONH-C3-PEG3-NH2 is a linker used in the synthesis of the PROTAC degrader 22-SLF.

Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand for the E3 ubiquitin ligase. This compound can form 22-SLF by linking with protein ligands through a connector.