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  • FKBP
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  • PROTACs
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  • Ligands for Target Protein for PROTAC
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Results for "

slf

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    20
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    14
    TargetMol | PROTAC
  • Recombinant Protein
    7
    TargetMol | Recombinant_Protein
  • Antibody Products
    3
    TargetMol | Antibody_Products
SLF
T13888195513-96-3
SLF is a synthetic ligand for FKBP12, which increases Ca2+ efflux and protein synthesis to improve skeletal muscle function, and is used in the study of central nervous system diseases and cancer.
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7-10 days
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SLF-amido-C2-COOH
PROTAC FKBP12-binding moiety 1
T139141092369-24-8
SLF-amido-C2-COOH (ZZY01-083) is an FKBP ligand with potential antimicrobial activity for the synthesis of PROTAC.
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KB02-SLF
T18061
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, also known as a molecular glue, that facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, thus forming KB02-SLF[1] and enhancing the longevity of protein degradation in biological systems.
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10-SLF
T2056122765058-89-5
10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.
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SLF TFA
T738172378802-47-0
SLF TFA, a synthetic ligand for FK506-binding protein (FKBP), exhibits affinity toward FKBP51 with a value of 3.1 μM and demonstrates an IC50 of 2.6 μM for FKBP12. This compound is utilized in the synthesis of PROTAC [1] [2] [3].
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22-SLF
T89030
22-SLF is a PROTAC degrader that operates by FBXO22-dependent degradation of FK506 Binding Protein 12 (FKBP12) with a DC50 of 0.5 µM. Additionally, 22-SLF can degrade other endogenous proteins, such as BRD4 and the EML4-ALK fusion protein (EML4-ALK fusion protein).
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dFKBP-1
T185971799711-22-0
dFKBP-1 is a potent PROTAC-based FKBP12 degrader incorporating the FKBP12 ligand SLF, the Thalidomide-based cereblon ligand, and a linker[1].
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E3 Ligase Ligand-linker Conjugate 139
T2014552375197-04-7
E3 Ligase Ligand-linker Conjugate 139 is an E3 ubiquitin ligase ligand and linker for PROTACKB03-SLF, used in cancer research.
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E3 ligase Ligand 41
T2014802375196-68-0
E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.
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KB02-COOH
KB02-COOH
T399232375196-30-6
KB02-COOH is a synthetic fragment derived from ubiquitin E3 ligase ligand KB02, which possesses potential utility in the synthesis of PROTAC compounds. Notably, KB02-COOH can be employed in the generation of PROTAC constructs like KB02-JQ1 and KB02-SLF.
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7-10 days
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AUTAC2
T740262241669-08-7
AUTAC2, an autophagy-mediated degrader (AUTAC) targeting FKBP12, comprises an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. The SLF component binds non-covalently to FKBP12 [1].
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TSPO ligand-3
T809282241669-89-4
TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the substantial inhibition of FKBP12 in HeLa cells [1].
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HO-CONH-C3-PEG3-NH2
T895402136574-39-3
HO-CONH-C3-PEG3-NH2 is a linker used in the synthesis of the PROTAC degrader 22-SLF.
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Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph
T89545
Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand for the E3 ubiquitin ligase. This compound can form 22-SLF by linking with protein ligands through a connector.
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