sedative-hypnotic

(E)-Crotylbarbital (Kalypnon), an isomer of Crotylbarbital, is a barbiturate derivative that has sedative, hypnotic, and anticonvulsant effects. (E)-Crotylbarbital can be used in studies to promote mental stability and sleep.

AZD 3043 (THRX 918661) is a variant modulator of the γ-aminobutyric acid type A receptor, a novel sedative-hypnotic and a potential short-acting anesthetic that produces hypnosis and EEG suppression in rats.AZD 3043 potentiates the γ-aminobutyric acid type A receptor and inhibits neuronal nicotinic acetylcholine receptors.

Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide.

Chlorobutanol (Chlortran) is a chemical preservative, sedative hypnotic and weak local anaesthetic. It has Antibacterial and Antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long-term stability to multi-ingredient formulations.

2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). It activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery [1]. [1]. Nikhil K Parelkar, et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.

Alloepipregnanolone is a pregnane with anesthetic, hypnotic, and sedative properties.

Alimemazine hemitartrate (Trimeprazine hemitartrate) is aphenothiazine derivative that is used as an antipruritic. It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness.

Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity.

Etoxybamide is a drug candidate for sedative (hypnotic).

Lvguidingan is an Anticonvulsant agent.

Apronal (Apronalide) has the hypnotic and sedative capacity and can be used for studies about neuropsychiatry disorders.

YGZ-331, a sedative hypnotic, acts by elevating GABA levels as a derivative of the adenosine nucleoside NGBA. It functions through activating A1R and A2aR, and inhibiting the phosphorylation of CaMKII (pCaMKII), thereby exerting its calming effects. Additionally, YGZ-331 reduces spontaneous motor activity in mice.

Benolizime is a compound utilized for its sedative and hypnotic properties.

Ethyl carfluzepate, a benzodiazepine derivative, exhibits chemical similarities with ethyl loflazepate, except for the missing methylcarbamoyl group. This compound primarily demonstrates sedative and hypnotic properties.

Probarbital (also known as ethyl isopropyl barbituric acid) is utilized as a hypnotic and sedative.

Penthrichloral exhibits sedative and hypnotic effects similar to chloral hydrate, but with a more pleasant taste and reduced gastric irritation. Additionally, Penthrichloral is also employed as an adhesive for polyester fibers.

Brallobarbital, known for its sedative and hypnotic properties, is a component of Vesparax used to treat sleep disorders. However, studies have identified Brallobarbital as the cause of toxicity issues associated with Vesparax.

Pyrithyldione is a sedative-hypnotic agent known to potentially induce agranulocytosis.

GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.

Acebrochol is a neuroactive steroid. It may act as a sedative and hypnotic, by the mechanism of altering ligand-gated ion channels and cell surface receptors.

JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic.

Capuride is a sedative with hypnotic properties and possible anticonvulsant activity.

Chlormethiazole edisylate is a positive allosteric modulator of the GABAA receptor. Chlormethiazole edisylate is a sedative and hypnotic.

PF 0713, a GABAA receptor agonist, is used as an intravenous sedative-hypnotic for general anaesthesia, ICU sedation, procedural sedation, chemotherapy.