polygala

Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly i

Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and can suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2).

Polygalaxanthone XI is an xanthone glycoside isolated from the cortex of Polygala tenuifolia, which can be used in studies of expectorants and to promote psychostability.

Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.

Polygalacic acid (Virgaureagenin G) is a triterpenoid isolated from the root of Polygala tenuifolia Willd that inhibits MMP expression. Polygalacic acid (Virgaureagenin G) can significantly improve the responsiveness of the cholinergic system, such as decreased acetylcholinesterase (AChE) activity, increased choline acetyltransferase (ChAT) activity, and increased acetylcholine (ACh) levels in the hippocampus and frontal cortex. Polygalacic acid (Virgaureagenin G) can also inhibit IL-1β-induced Wnt β-catenin activation and mitogen-activated protein kinase (MAPK) signaling pathways in chondrocytes, and is used in osteoarthritis (OA) related research.

Polygalasaponin possesses evident anxiolytic and sedative-hypnotic activities and has a relatively safe dose range, which supports the use of Polygala tenuifolia root as an anxiolytic and sedative-hypnotic drug in folk medicine.

Polygalasaponin LII, a triterpenoid saponin, can be isolated from the roots of Polygala japonica Houtt [1].

Polygalacin D2 may have antimicrobial activity.

Polygalasaponin E is a natural product for research related to life sciences. The catalog number is TN6531 and the CAS number is 882664-72-4.

Polygalasaponin XLIX is a natural product for research related to life sciences. The catalog number is TN6532 and the CAS number is 1033593-12-2.

Polygalasaponin XXXV is a natural product for research related to life sciences. The catalog number is TN6533 and the CAS number is 184479-28-5.

Polygalasaponin XXVIII, a triterpenoid saponin, can be isolated from *Polygala japonica* Houtt. [1].

Polygalacturonic acid (Galacturonic acid polymer), a transparent colloid, constitutes a significant portion of the cell wall. It is employed in the synthesis of silver nanoparticles (AgNPs), serving both as an antioxidant and anti-inflammatory agent to shield cells from the harmful impacts of elevated reactive oxygen species (ROS) and to expedite wound healing. Additionally, Polygalacturonic acid nanoparticles exhibit antibacterial properties [1] [2].

Polygalasaponin XXXII is a natural product that can be used in related research in the field of life sciences. Its product number is TN8602.

3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA BZ receptor complex.

1. Sibiricose A6 displays antidepressant-like action, it may prevent or relieve depression. 2. Sibiricose A6 shows potent antioxidant activity.

7-O-MethylMangiferin is an xanthone isolated from the rhizomes of Iris nigricans.

Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice.

Glomeratose A, a lactate dehydrogenase inhibitor (LDH), [Compound BBX] is a small molecule that targets enzyme inhibitors (MJBB-_13798), effectively reducing lactate production in cells, thereby influencing metabolic processes and demonstrating potential therapeutic applications in conditions characterized by elevated lactate levels.

Sibiricose A3 is a compound isolated from the roots of Polygala sibirica L. It is used in the study of prostate cancer.

Tenuifoliside C, isolated from Polygala tenuifolia Willd, is a targeted lactate dehydrogenase inhibitor that significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1].

3',6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats.

Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.

Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.