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Results for "

platelet activating factor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    111
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • Natural Products
    33
    TargetMol | Natural_Products
  • Recombinant Protein
    3
    TargetMol | Recombinant_Protein
  • Isotope Products
    1
    TargetMol | Isotope_Products
  • Antibody Products
    2
    TargetMol | Antibody_Products
48740 rp
RP-55778, RP-48740, RP 55779, RP 55778
T1015993363-11-2In house
48740 RP (RP 55779) is an antagonist of platelet-activating factor.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Hot
PAF (C16)
C16-PAF
T2154774389-68-7In house
PAF (C16) is a potent MAPK and MEK ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Hot
Aglafoline
Rocaglamide U, Aglafolin, (-)-Methyl rocaglate
T10260143901-35-3In house
Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM.
  • Inquiry Price
3-6 months
Size
QTY
cp-96021 hydrochloride
T10872167011-22-5In house
CP-96021 hydrochloride is a potent and orally active antagonist of leukotriene D4 (LTD4) platelet activating factor receptor (Kis: 34 nM and 37 nM).
  • Inquiry Price
1-2 weeks
Size
QTY
PAF-AN-1
T14007115621-84-6In house
PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.
  • Inquiry Price
6-8 weeks
Size
QTY
Tulopafant
RP 59227
T17178116289-53-3In house
Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.
  • Inquiry Price
6-8 weeks
Size
QTY
CV-6209
CV6209, CV 6209
T27102100488-87-7In house
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.
  • Inquiry Price
6-8 weeks
Size
QTY
DF-1111301
DF1111301, DF 1111301
T27159160665-99-6In house
DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol
(Rac)-Modipafant
UK 74505, UK74505, UK-74505, Modipafant racemate
T28081122956-68-7In house
(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia reperfusion (I R) in the superior mesenteric artery (SMA) of the rat.
  • Inquiry Price
8-10 weeks
Size
QTY
Rocepafant
LAU 8080, LAU8080, BN 50730, LAU-8080, BN50730, BN-50730
T28607132579-32-9In house
Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.
  • Inquiry Price
6-8weeks
Size
QTY
TargetMol | Inhibitor Sale
SDZ-62-434
SDZ62434, SDZ 62 434
T28740115621-95-9In house
SDZ-62-434, a platelet-activating factor inhibitor with antitumor activity, inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells, making it a potential candidate for studying leukemia, human xenograft colorectal cancer, and lung cancer.
  • Inquiry Price
6-8 weeks
Size
QTY
Pirodomast
T67959108310-20-9In house
Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospasm induced by histamine, methacholine, serotonin, LTC4, or platelet-activating factor. Pirodomast is a potential antiallergic compound. Pirodomast had only weak relaxant activity on guinea pig trachea in vitro. Pirodomast is a potential antiallergic compound that inhibits the protein hydrolyzing activity of trypsin in vitro, prevents antigen-induced immediate and late asthmatic responses in allergic sheep in vivo, and inhibits antigen-induced airway hyperresponsiveness to histamine and carbachol in allergic sheep.
  • Inquiry Price
6-8weeks
Size
QTY
TargetMol | Inhibitor Sale
Dersalazine
Dersalazine Free Base
T70084188913-58-8In house
Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis.
  • Inquiry Price
6-8weeks
Size
QTY
TargetMol | Inhibitor Sale
BIRM 271
T77638149106-77-4In house
BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leukotriene B4 with IC50 of 40 nM.
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QTY
TargetMol | Inhibitor Sale
PAF C-18
PAF (C18)
T3676374389-69-8
PAF C-18 is a naturally occurring phospholipid molecule belonging to the platelet-activating factor (PAF) family, which acts as an intercellular signaling molecule involved in platelet aggregation, vasodilatation, and inflammatory responses.PAF C-18 is involved in hemostasis and thrombosis by binding to its specific G-protein-coupled receptor (PAFR) and activating.
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CP-96486
T10873139401-45-9In house
CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4) and platelet activating factor (PAF) receptors, with inhibitory constants (Kis) of 20 and 24 nM, respectively.
  • Inquiry Price
8-10 weeks
Size
QTY
Rupatadine
UR-12592, UR12592
T36618158876-82-5
Rupatadine (UR-12592, rupatadine) is a potent and orally available dual antagonist of PAF and histamine H1 receptors with Ki values of 0.55 μM and 0.1 μM, respectively, which provides relief of allergic symptoms and anti-inflammatory properties, and is used in allergic rhinitis and chronic urticaria.
  • Inquiry Price
7-10 days
Size
QTY
Emedastine
LY188695, Emadine
T397987233-61-2
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.
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Foropafant
SR27417
T15338136468-36-5
Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
SCH-37370
T19686117796-52-8
SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM).
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TargetMol | Inhibitor Sale
CMI-392
T10844205654-37-1
CMI-392 is a dual inhibitor of 5-lipoxygenase and a receptor antagonist for platelet-activating factor (PAF) with IC50 values of 100 nM and 10 nM, respectively.
  • Inquiry Price
8-10 weeks
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QTY
TCV-309 chloride
T13103121494-09-5
TCV-309 chloride is an antagonist of platelet activating factor (PAF).
  • Inquiry Price
6-8 weeks
Size
QTY
YM-264
T13369131888-54-5
YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes).
  • Inquiry Price
6-8 weeks
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QTY
(+)-Guaiacin
T1371688547-66-4
(+)-Guaiacin, isolated from the bark of Machilus wangchiana Chun, demonstrates potent in vitro inhibition of β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF).
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