pkr 1

PKR1 antagonist 1 (PC1) is a potent PKR1 antagonist that effectively alleviates hyperalgesia and allodynia in SNI mice. PKR1 antagonist 1 can be used in research on pain, inflammation, and neurobiology.

PKR1 antagonist 1 HCl (PC1 HCl) is a highly potent, non-peptide PKR1 antagonist that reduces pain behavior and spinal neuron sensitization in neuropathic mice.

PKR activator 1 is a potent activator of pyruvate kinase-R (PKR).

PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).

(Rac)-Etavopivat ((Rac)-FT-4202), an isomer of Etavopivat, is an orally active erythrocyte pyruvate kinase-R (PKR) activator used in sickle cell disease and haemoglobinopathy research [1].

Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.

GCN2 activator-1 (Compound 20) is a GCN2 activator that binds to the ATP pocket of GCN2 and activates it in a GCN1-independent manner. It can stimulate the integrated stress response (ISR) in cells and inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 is utilized for research on pulmonary veno-occlusive disease (PVOD).

PKR activator 4 (example 7A), a potent activator of pyruvate kinase R (PKR), holds promise for blood disorder research [1].