peptide 78

Peptide 78 is identical to peptide 74 except that serine replaces cysteine. It does not inhibit 72-kDa type IV collagenase.

Pexiganan (MSI 78 free base), a synthetic analog of magainin 2, is a potent, broad-spectrum antimicrobial peptide with oral activity. It is utilized in researching infections, including diabetic foot ulcer infections [1].

Maximin 78 is an antimicrobial peptide with antibacterial activity against C. albicans, S. aureus, and B. subtilis, exhibiting minimum inhibitory concentrations (MIC) of 37.5, 4.7, and 37.5 μg/mL, respectively. Additionally, this compound has hemolytic activities against human and rabbit red cells [1].

Pexiganan acetate (MSI 78) is a synthetic cationic peptide composed of 22 amino acids and demonstrates potent antibacterial activity. Pexiganan acetate is an analogue of magainin 2, which is a naturally occurring host defense peptide originally isolated from frog skin. The antibacterial action of Pexiganan acetate is thought to involve disruption of the integrity and permeability of the bacterial cell membrane or cell wall, leading to bacterial cell death.