oligomycin

Oligomycin is a macrolide antibiotic produced by Streptomyces. Oligomycin is commonly used to study mitochondrial function and cellular energy metabolism and has antifungal and antitumor activities.

Oligomycin E is a minor metabolite of the oligomycin complex produced by several species of Streptomyces. It exhibits relatively weak antifungal activity compared to other oligomycins, yet is active against Gram-positive bacteria and demonstrates strong antitumor activity against HeLa cells (IC50 = 14 ng/ml).

Oligomycin B, an antibiotic isolated from marine Streptomyces, serves as an eukaryotic ATP synthase inhibitor and induces apoptosis.

Oligomycin C is an antifungal agent isolated from Streptomyces strain.

Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.

Rutamycin is a macrolide antibiotic of the oligomycin group obtained from Streptomyces rutgersensis. It inhibits various ATPases and uncouples oxidative phosphorylation from electron transport.

44-Homooligomycin A is an antitumor antibiotic. It exhibits activity against fungi such as Aspergillus, Penicillium, and Fusarium, but it is ineffective against yeast and bacteria. In vivo, 44-Homooligomycin A demonstrates moderate antitumor potency against colon 26.

44-Homooligomycin B is an antitumor antibiotic. It exhibits activity against fungi such as Aspergillus, Penicillium, and Fusarium species but does not affect yeast and bacteria. In vivo, 44-Homooligomycin B demonstrates moderate antitumor activity against Colon 26.

Tetradifon is a broad-spectrum organochlorine acaricide insecticide and a potent inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP)，a subunit of ATP synthase. Tetradifon is utilized for controlling a variety of mite pests and inhibiting energy-related mitochondrial activities including ADP-stimulated respiration and ATPase activity with an IC50 range of 4.5-27 nmoL/mg mitochondrial protein; it exerts oligomycin-like effects by inhibiting oxidative phosphorylation, inducing significant oxidative stress, and interfering with bone metabolism, making it a compound of interest for researching mitochondrial function, bone remodeling mechanisms, and nephrotoxicity.

(S)-IB-96212 (compound 4) is an oligomycin derivative that inhibits the MurD2 reaction but does not affect the MurL reaction. This compound specifically targets and inhibits a bypass pathway of peptidoglycan biosynthesis. Additionally, (S)-IB-96212 exhibits weak inhibition of the MurD reaction.