oligomycin

Oligomycin is a macrolide antibiotic produced by Streptomyces. Oligomycin is commonly used to study mitochondrial function and cellular energy metabolism and has antifungal and antitumor activities.

Oligomycin B, an antibiotic isolated from marine Streptomyces, serves as an eukaryotic ATP synthase inhibitor and induces apoptosis.

Oligomycin C is an antifungal agent isolated from Streptomyces strain.

Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.

44-Homooligomycin A is an antitumor antibiotic. It exhibits activity against fungi such as Aspergillus, Penicillium, and Fusarium, but it is ineffective against yeast and bacteria. In vivo, 44-Homooligomycin A demonstrates moderate antitumor potency against colon 26.

44-Homooligomycin B is an antitumor antibiotic. It exhibits activity against fungi such as Aspergillus, Penicillium, and Fusarium species but does not affect yeast and bacteria. In vivo, 44-Homooligomycin B demonstrates moderate antitumor activity against Colon 26.