olfactory

Picaridin (Lcaridin) is a topical insect repellent.

Allocholic acid is a fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis. It is also a potent and specific stimulant of the adult olfactory system.

(-)-Perillaldehyde shows antibacterial activity.

Sandalore prolongs human hair growth by decreasing apoptosis and increasing the production of the anagen-prolonging growth factor IGF-1 in the outer root sheath. Sandalore is a selective agonist of olfactory receptor OR2AT4.

Sandacanol(Sandranol) is a selective olfactory receptor (OR10H1) agonist. Sandacanol can induce cell cycle arrest and partial apoptosis in bladder cancer cells, and can reduce cell migration rate and proliferation rate.

11-cis-Vaccenyl acetate ((Z)-Octadec-11-enyl acetate) activates olfactory neurons located in the T1 sensilla on the antenna and mediates aggregation behavior in both male and female flies.

(±)-Perillaldehyde exhibits antidepressant effects in mice with stress-induced depressive-like behavior by modulating the olfactory nervous system. Additionally, it demonstrates anti-inflammatory activity by activating JNK in RAW264.7 cells and suppressing the expression of TNF-α, with an IC50 value of 171.7 μM.

RG-15 is an orally active dopamine receptor antagonist with high affinity for the human D2 receptor (pKi of 8.23) and human D3 receptor (pKi of 10.49). It inhibits dopamine-stimulated [35S]GTPγS binding with IC50 values of 21.2 nM in rat striatal membranes, 36.7 nM in mouse A9 cells expressing human D2L receptors, and 7.2 nM in CHO cells expressing human D3 receptors. RG-15 enhances dopamine turnover and synthesis in the striatum and olfactory bulb of mice, exhibiting antipsychotic activity.

VU0183254 is an insect olfactory receptors (ORs) agonist acting at a binding site on the Orco subunit, capable of broadly inhibiting odor-mediated OR complex activation.

Dichlobenil (2,6-dichloro-Benzonitrile) is a herbicide widely used for weed control, an olfactory toxicant, and a cellulose biosynthesis inhibitor.

Satratoxin G is a trichothecene mycotoxin of Stachybotrys chartarum and has been shown to selectively induces apoptosis in olfactory sensory neurons (OSNs) of the nose and brain.

Petromyzonol is a tetrahydroxy stearol which serves as the primary spawning pheromone in adult sea lamprey. It is produced in the bile of sea lamprey larvae from the bile acid precursor allocholic acid. While the adult sea lamprey is relatively insensitive to petromyzonol itself, the C-24 sulfate ester (petromyzonol sulfate) is a pheromone and a spawning chemoattractant which can be detected at very low concentrations by lamprey olfactory chemoreceptors. Petromyzonol, petromyzonol sulfate, and allocholic acid are all found in water samples from fresh water streams bearing larval lamprey populations.[1]

Bourgeonal is an agonist of human testicular olfactory receptor hOR17-4. It increases cytosolic calcium levels in human spermatozoa, acts as a chemoattractant, and increases swimming speed in sperm chemotaxis assays in a concentration-dependent manner.

5-Cyclopropylpentanal, an olfactory receptor agonist, effectively enhances OR-I7 activation, demonstrating an EC50 value of 0.3 μM.

VUAA1, an insect odorant co-receptor (Orco) agonist, activates heteromeric and homomeric Orco-containing channels and can disrupt the behaviors of nuisance insects, thus serving as a tool for insect olfactory research [1] [2].

6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine, an alkaloid, significantly alters the characteristics of early endosomes, mitochondria, and autophagosomes in Parkinson's Disease patient-derived olfactory cells [1].

4A7C-301, a Nurr1 agonist, exhibits potent neuroprotective effects in vitro and markedly mitigates neuropathological abnormalities while enhancing motor and olfactory functions in male mouse models with AAV2-mediated α-synuclein overexpression. This compound is applicable in Parkinson's disease research [1].

The compound 4A7C-301-Nurr1 agonist is a specific agonist for the nuclear receptor-related 1 (Nurr1). By binding to the Nurr1 ligand-binding domain with an IC50 value of 48.22 nM, it enhances the transcriptional activity of both Nurr1-LBD and the full-length Nurr1, as demonstrated in reporter assays using SK-N-BE(2)C human neuroblastoma cells, with EC50 values of 6.53 and 50-70 µM, respectively. Additionally, administration of 4A7C-301-Nurr1 agonist at a dosage of 5 mg/kg per day has been shown to mitigate dopaminergic cell death in the striatum and substantia nigra pars compacta and ameliorate motor and olfactory deficits in mouse models of Parkinson's disease, circumventing the induction of dyskinesia-like behaviors. These models were induced either by the neurotoxin MPTP or by overexpression of α-synuclein.

8-Pcpt-cGMP acts as an agonist for cyclic nucleotide-gated (CNG) channels with an EC50 of 0.5 μM and exhibits good membrane permeability. This compound is utilized in research to explore the role of CNG channels in visual and olfactory signal transduction.

Dichlobenil (Standard) is the standard substance of Dichlobenil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Dichlobenil (2,6-dichloro-Benzonitrile) is a herbicide widely used for weed control, an olfactory toxicant, and a cellulose biosynthesis inhibitor.

Allocholic acid (Standard) is a reference standard for research and analysis in studies involving Allocholic acid. Allocholic acid is a major component in bile from the river carpsucker, Carpiodes carpio. Allocholic acid is a potent and specific stimulant of the adult olfactory system and function as migratory pheromones in lamprey.

(S)-2-Hydroxy-3-decanone is the key pheromone component of the Xylotrechus quadripes beetle, acting as a volatile olfactory stimulant. It holds potential for research in pest and disease management.

alpha-Ionone acts as an agonist for the olfactory receptor OR10A6. It induces apoptosis by activating OR10A6 and increasing the phosphorylation level of the LATS-YAP-TAZ signaling axis in the Hippo pathway, thereby inhibiting tumorigenesis and tumor progression in both in vitro and in vivo experiments.

Valerena-4,7(11)-diene, a tranquilizer, suppresses stress-induced excitatory behaviors and is administered through olfactory stimulation and pulmonary absorption [1].