ntpdase1

TcNTPDase1-IN-1 (compound 16) serves as an inhibitor of nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1) from Trypanosoma cruzi in vitro. This compound is applicable in research related to antibacterial, antitoxic, and antitumor activities.

h-NTPDase-IN-2 is a broad-spectrum NTPDase inhibitor that inhibits multiple h-NTPDas isoforms.

h-NTPDase-IN-3 is an h-NTPDase inhibitor that inhibits h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NTPDase8.

Sodium metatungstate (Sodium polyoxotungstate) is a potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), with Ki values of 2.58 μM for NTPDase 1, 3.26 μM for NTPDase 3, and 28.8 μM for NTPDase 2.

ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt is an inhibitor of ecto-ATPase.

NTPDase-IN-1 (compound 5a) is a selective inhibitor of NTPDase enzymes with IC50 values of 0.05 μM, 0.23 μM, and 0.54 μM against h-NTPDase-1, h-NTPDase-2, and h-NTPDase-8, respectively. It exerts non-competitive inhibition on h-NTPDase-1 and h-NTPDase-2, with a Km value of 21 μM for h-NTPDase-1. This compound is useful for investigating conditions such as cancer, immunologic disorders, and bacterial infections [1].

NTPDase-IN-3 (Compound 5e), an inhibitor of NTPDase, exhibits IC50 values of 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2). It is utilized in cancer and thrombosis research [1].

NTPDase-IN-2 (compound 5g) selectively inhibits NTPDase-2 and NTPDase-8 with IC50 values of 0.04 µM and 2.27 µM, respectively, and exhibits non-competitive inhibition toward h-NTPDase-1 and h-NTPDase-2, with a Km of 74 µM for h-NTPDase-2. This compound is applicable in researching cancer, immunological disorders, and bacterial infections [1].

ARL67156 (FPL 67156) trisodium hydrate is a selective ecto-ATPase inhibitor and a competitive inhibitor of NTPDase1 (CD39), NTPDase3, and NPP1, with K i values of 11, 18, and 12 μM respectively. It is used in research of diseases such as calcific aortic valve disease and asthma [1] [2].

ARL67156 (FPL 67156) triethylamine, a selective ecto-ATPase inhibitor, functions as a competitive inhibitor for NTPDase1 (CD39), NTPDase3, and NPP1, exhibiting inhibition constants (Kis) of 11, 18, and 12 μM, respectively. This compound is applicable in researching diseases such as calcific aortic valve disease and asthma [1] [2].

h-NTPDase-IN-4 is a pan-inhibitor of NTPDase, which can inhibit h-NTPDase1, 1h-NTPDase2, h-NTPDase3, h-NTPDase8. The IC50 values were 3.58 μM, 10.21 μM, 0.13 μM and 13.57 μM, respectively.

h-NTPDase-IN-1 (Compound 3i) is an inhibitor of human NTPDase with IC50 values of 2.88 μM for h-NTPDase1 and 0.72 μM for h-NTPDase3, indicating potential utility for thrombosis, inflammation, diabetes, and cancer research [1].

h-NTPDase-IN-5 (compound 3b) serves as a pan-inhibitor of NTPDase, exhibiting inhibitory concentration 50 (IC50) values of 1.10 μM [h-NTPDase1], 44.73 μM [h-NTPDase2], 26.14 μM [h-NTPDase3], and 0.32 μM [h-NTPDase8].