ntpdase 1

NTPDase-IN-1 (compound 5a) is a selective inhibitor of NTPDase enzymes with IC50 values of 0.05 μM, 0.23 μM, and 0.54 μM against h-NTPDase-1, h-NTPDase-2, and h-NTPDase-8, respectively. It exerts non-competitive inhibition on h-NTPDase-1 and h-NTPDase-2, with a Km value of 21 μM for h-NTPDase-1. This compound is useful for investigating conditions such as cancer, immunologic disorders, and bacterial infections [1].

h-NTPDase-IN-1 (Compound 3i) is an inhibitor of human NTPDase with IC50 values of 2.88 μM for h-NTPDase1 and 0.72 μM for h-NTPDase3, indicating potential utility for thrombosis, inflammation, diabetes, and cancer research [1].

h-NTPDase8-IN-1 is a specific aminosulfonylbenzamide inhibitor of h-NTPDases8 (IC 50 = 0.28 ± 0.07 μM). h-NTPDase8-IN-1 can be used to study diseases brought about by aberrant h -NTPDase expression.

Sodium metatungstate (Sodium polyoxotungstate) is a potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), with Ki values of 2.58 μM for NTPDase 1, 3.26 μM for NTPDase 3, and 28.8 μM for NTPDase 2.

NTPDase-IN-3 (Compound 5e), an inhibitor of NTPDase, exhibits IC50 values of 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2). It is utilized in cancer and thrombosis research [1].

NTPDase-IN-2 (compound 5g) selectively inhibits NTPDase-2 and NTPDase-8 with IC50 values of 0.04 µM and 2.27 µM, respectively, and exhibits non-competitive inhibition toward h-NTPDase-1 and h-NTPDase-2, with a Km of 74 µM for h-NTPDase-2. This compound is applicable in researching cancer, immunological disorders, and bacterial infections [1].