nocodazole

Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.

BAY-1816032 is a benzimidazole budding inhibition relieved homolog protein 1 kinase (BUB1) inhibitor with IC50 of 7 nM and is orally active and abolishes nocodazole-induced Thr-120 phosphorylation of histone H2A, a major BUB1 target protein, in HeLa cells with IC50 of 29 nM.

Tubulin polymerization-IN-90 is an inhibitor of tubulin polymerization. It disrupts tubulin assembly by binding to the nocodazole binding site on β-tubulin. This compound induces the release of extracellular vesicles marked by the tetraspanin CD63 and stimulates cells to release IL-8. Tubulin polymerization-IN-90 also reduces cancer cell viability and is utilized in research on cancers such as acute T-cell lymphoblastic leukemia.

ANK peptide is a novel peptide designed based on the conserved residue of a single-anchored protein motif. It acts as an inhibitor of γ-synuclein (SNCG) by binding to SNCG, thereby competing with and disrupting the SNCG-BubR1 interaction. This action enhances the sensitivity of breast cancer cells to antimicrotubule agents such as nocodazole and paclitaxel. ANK peptide is useful for tumor research.

Boc-AEVD-CHO TFA is a Caspase 8 inhibitor. By inhibiting apoptosis, Boc-AEVD-CHO TFA significantly increases the frequency of micronuclei (MN) and binucleated micro-nucleated cells (MNCB) in peripheral blood mononuclear cells (PBMC) when induced by Nocodazole or methyl methanesulfonate (MMS). This compound is useful for research in immune and inflammatory diseases.