nifedipine

Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

m-Nifedipine, an impurity of Nifedipine, serves as a potent calcium channel blocker and the preferred treatment option for cardiac insufficiencies.

Nifedipine HCl is a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Nifedipine-D6 is deuterium labeled nifedipine (T1146) which is a potent blocker of calcium channel.

Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.

Nifedipine-13C8 (Standard) is a reference standard of Nifedipine-13C8 intended for quantitative analysis, quality control, and related biochemical research applications. Nifedipine-13C8 is a deuterium-labeled form of Nifedipine. Nifedipine (BAY-a-1040) acts as an effective calcium channel blocker, frequently utilized in studies related to myocardial dysfunction.

Nifedipine-D6 (Standard) is a reference standard of Nifedipine-D6 intended for quantitative analysis, quality control, and related biochemical research applications.

Oxidised nifedipine-D6 is the deuterated form of Oxidised nifedipine (T36665) and can be used for isotope tracing.

Oxidised Nifedipine-D6 (Standard) is a reference standard of Oxidised Nifedipine-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Oxidised nifedipine-d6 is the deuterated form of Oxidised nifedipine and can be used for isotope tracing.

Hydroxydehydro nifedipine carboxylate is a metabolite of nifedipine .1 1.Roosemalen, M.C.M., Soons, P.A., Funaki, T., et al.High-performance liquid chromatographic determination of the polar metabolites of nifedipine in plasma, blood and urineJ. Chromatogr.565(1-2)516-522(1991)

Nifedipine-13C8 is a deuterium-labeled form of Nifedipine. Nifedipine (T1146) (BAY-a-1040) acts as an effective calcium channel blocker, frequently utilized in studies related to myocardial dysfunction.

Nifedipine-D4 is the deuterated form of Nifedipine. Nifedipine (T1146) (BAY-a-1040) is a potent calcium channel blocker widely used in studies related to myocardial dysfunction.

Nifedipine nitroso-d6 is the deuterium-labeled form of Nifedipine nitroso.

Dehydro Nifedipine (Standard) is the standard substance of Dehydro Nifedipine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.

Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.

Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator.

AK-2-38 is a nifedipine analogue with potent smooth muscle calcium antagonist action and partial agonist effects on isolated guinea pig left atrium.

Nirudipine is a double (2-propoxyethyl) analogist of nifedipine and a calcium channel blocker, which is also a safe anti-angina Ca2+ antagonist with a broad range of efficacy for all types of angina. At the same time, Niludipine is a highly effective drug

5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 μM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5(6)-EET is provided as a mixture of the free acid and lactone.

FR-7534 is a calcium antagonist structurally similar to nifedipine.

Nitrendipine (Standard) is the standard substance of Nitrendipine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.

5-O-Methylnaringenin is a marker, reduced MS detection of 5-O-methylnaringenin indicated that nifedipine may preferably remove a proton from the 5-position OH group in the A ring of the flavonoid skeleton.