ms-98

MS98 is a highly effective and specific PROTAC AKT degrader compound that effectively targets and depletes total AKT (T-AKT) within cells, exhibiting a DC 50 value of 78 nM. This compound readily binds to AKT1, AKT2, and AKT3 with respective dissociation constants (Kd s) of 4 nM, 140 nM, and 8.1 nM.

BMS-986449 is an IKZF2 (Helios)/IKZF4 (Eos) degrader and CELMoD molecular glue. It redirects the interaction between the E3 ubiquitin ligase Cereblon and Helios/Eos in primary Treg cells, inducing their degradation, and may be utilised for anti-tumour immunotherapy.

BMS-986470 is a CRBN E3 ubiquitin ligase modulator (CELMoD) that can activate fetal hemoglobin (HbF). It is an orally-administered dual-target molecular glue degrader, primarily acting on ZBTB7A and WIZ proteins. This compound can significantly promote the expression of γ-globin and has significant application value in the study of sickle cell disease (SCD).

BMS-986458 is a highly selective, orally active BCL6 PROTAC degrader. It specifically targets cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity-induced BCL6 degradation. BMS-986458 is applicable for research in B-cell non-Hodgkin lymphoma.

BMS-986397 is a casein kinase 1 α molecular gel degrading agent based on cereblon, which can promote rapid apoptosis and cell cycle arrest of TP53 wild-type acute myeloid leukemia cells.