mps-1-in-1

Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM).

Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) function, thereby reducing the viability of both cancerous and 'normal' cells.

Mps1-IN-10 is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects on breast cancer cells.

Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).

Mps1-IN-2 is a potent, selective, and ATP-competitive inhibitor of both Mps1 and Plk1.

TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin-trapping agent that targets free radicals. It scavenges superoxide anions and hydroxyl radicals, and inhibits thymocyte apoptosis with an EC50 value of 19.1 mM for DNA fragmentation induced by MPS and 30.7 mM by Etoposide. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, thereby reducing oxidative stress (such as lowering peroxide levels and maintaining glutathione content) and blocking oxidative events in the apoptosis pathway. TMPO shows potential for research in apoptosis of immune cells like thymocytes.

Valanafusp alfa (AGT-181) is a recombinant fusion protein combining a chimeric monoclonal antibody targeting the human insulin receptor (HIR) with human iduronidase (IDUA), facilitating brain penetration, and is utilized in researching Mucopolysaccharidosis type I (MPS I) [1].

Polystyrene microplastics (PS-MPs) are a toxic substance that poses risks to aquatic life, specifically causing cardiac harm to zebrafish and inducing male reproductive toxicity in mice [1] [2].

Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accumulation within the central nervous system of mucopolysaccharidosis II (MPS II) mice. It enhances cognitive function and protects against neuronal damage in the central nervous system [1].

Membrane-Permeable Sequence (MPS) is a cell-penetrating peptide (CPP) utilized in the investigation of membrane crossing mechanisms [1].