mannosidase

Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.

D-(-)-Quinic acid (Kinic acid) is a cellular metal ion chelator, capable of promoting reactions with metal M(II,III) ions under pH-specific conditions. It may possess potent inhibition against alpha-mannosidase and alpha-fucosidase.

Kifunensine, an alkaloid discovered in Kitasatosporia kifunense, functions as a glycosylation pathway inhibitor and immunomodulator. It strongly inhibits α-mannosidase I in the Golgi apparatus and may be utilised in studies of endoplasmic reticulum stress.

1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity.

Plantagoside is a specific non-competitive inhibitor for jack bean alpha-mannosidase (IC50: 5 μM). It also is a potent inhibitor of the Maillard reaction.

Panosialin wA inhibits α,β-glucosidase and mannosidase enzymes, but does not exhibit inhibitory activity against the influenza virus. However, it has a mild antibacterial effect.