ksp

SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).

Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.

ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity.

PROTACKSP-IN-1 (Compound 21) is a spindle protein (KSP) degrader as a PROTAC, effectively degrading KSP in HCT-116 cells with a DC50 value of 114.8 nM. It inhibits the proliferation of HCT-116 with an IC50 of 10 nM, causes G2/M phase cell cycle arrest, and induces apoptosis in HCT-116. Additionally, PROTACKSP-IN-1 demonstrates antitumor activity in mouse models.

KSP ligand 1 is a protein ligand that targets KSP (Kinesin) and can be used in the synthesis of PROTAC KSP-IN-1 for cancer research.

KSP-IN-2 (compound 12) is an inhibitor of the kinesin spindle protein (KSP) with an IC50 of 450 nM.

KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.

Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic properties.

Larkspur alkaloid is a bioactive chemical.

KSPWFTTL is an immunodominant epitope derived from the p15E transmembrane protein. It is Kb-restricted and can enhance the susceptibility of a tumor cell line to cytotoxic T lymphocytes targeting anti-AKR/Gross MuLV.

Phenylethyl isothiocyanate (JC5411) is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.

MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in

Ispinesib (SB-715992) mesylate is a specific inhibitor of the spindle motor protein KSP, with a Ki app value of 1.7 nM.

Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during

Photoclick sphingosine (Pacsph) is a photosensitive and clickable analog of sphingosine. Once inside cells, it is metabolized into the endogenous lipid metabolic pathways and can be visualized via its clickable alkyne group. This compound is useful for studying intracellular sphingolipid metabolism and subcellular localization.

Myristoylated Alanine-Rich C Kinase Substrate peptide (151-175) is a high affinity Protein Kinase C substrate.

CKS peptide is a selective substrate peptide for CK1 and can be used to measure CK1 activity.

Photoclick Sphingosine-1-Phosphate is a clickable sphingolipid suitable for use in click chemistry reactions.

S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective for Eg5 over nine other human kinesins in an enzyme-coupled assay. It reversibly inhibits Eg5-driven microtubule sliding velocity with an IC50 value of 500 nM using X. laevis recombinant Eg5. It induces cell cycle arrest in HeLa cells (IC50 = 700 nM), reversibly halting the cell cycle in the mitotic phase by inhibiting the separation of duplicated chromosomes and preventing bipolar spindle formation. S-trityl-L-Cysteine inhibits the growth of cancer cells in vitro when tested against the National Cancer Institute (NCI) 60 human cancer cell line panel (average GI50 = 1.3 μM) and in mouse xenograft models.

(R)-Filanesib (ARRY-520) is a synthetic kinesin spindle protein (KSP) inhibitor with an IC₅₀ of approximately 6 nM. It inhibits KSP-mediated spindle formation, thereby inducing mitotic arrest and suppressing cell proliferation.

Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ, demonstrating efficacy against breast cancer.

ALN-3133 sodium is a siRNA targeting VEGF and is one of the siRNAs in ALN-VSP. ALN-VSP is a lipid nanoparticle formulation containing two siRNAs against kinesin spindle protein (KSP) and VEGF, offering potential antitumor activity.

ALN-12115 sodium is a siRNA targeting the microtubule motor protein (KSP) and is one of the siRNAs in ALN-VSP. ALN-VSP is a lipid nanoparticle formulation containing two siRNAs that target KSP and VEGF, offering potential antitumor activity.

ALN-12115 is an siRNA targeting the microtubule motor protein (KSP) and is part of ALN-VSP, a lipid nanoparticle formulation containing two siRNAs aimed at KSP and VEGF, with potential antitumor activity.