human ne

Centanafadine is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).

Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).

CathepsinG, human neutrophils (CTSH; ACC4), is a serine protease found in polymorphonuclear neutrophils (PMN), playing a role in the inflammatory response.

Myeloperoxidase, Human Neutrophil, is a peroxidase enzyme that acts as a potent antimicrobial agent by catalyzing the oxidation of chloride ions dependent on H2O2, producing hypochlorous acid. It also facilitates the degradation of N-retinylidene-N-retinyl-ethanolamine [a toxic form of retinal lipofuscin], and induces lysosomal stress and cell death. This enzyme is useful for research in inflammation and infection.

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.

Isopeonol (1-(4-hydroxy-2-methoxyphenyl)ethanone) is a useful life science reagent for biochemical experiments and organic synthesis.

FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef

Neuropeptide Y (human) is a biologically active 36-amino acid peptide.

Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with antiviral properties. It is effective against Escherichia coli, Enterococcus faecalis, and Candida albicans. It exhibits stronger bactericidal activity against Gram-negative bacteria compared to HNP-1 to HNP-3. Corticostatin, human TFA can be isolated from azurophilic granule fractions using a discontinuous Percoll gradient.

Levomilnacipran (F2696; (1R,2S)-milnacipran) is the enantiomer of milnacipran and acts as a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. It also serves as a human α-adrenergic receptor antagonist with an IC50 of 3.4 μM, as detailed in patent WO2013014263A1.

CHF-6333 xinafoate is a neutrophil elastase (NE) inhibitor with an IC50 of 0.21 nM and a KD of 0.16 nM. It exhibits activity against both human (IC50= 0.22 nM) and rat (IC50= 3.63 nM) proteases and also inhibits proteinase 3 with an IC50 of 22 nM. This compound is applicable in bronchiectasis (BE) research.

Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.

AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.

Ala-Ala-Pro-Val-chloromethylketone serves as an irreversible inhibitor of human neutrophil elastase (NE), utilized in researching chronic inflammatory airway diseases.

Dextromilnacipran-d6 ((1R,2S)-milnacipran-d6) is the deuterium-labelled form of Dextromilnacipran. As an enantiomer of Milnacipran, it functions as a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. Additionally, Dextromilnacipran serves as a human α-adrenergic receptor antagonist with an IC50 of 3.4 μM.