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Results for "

human 5-ht7 receptor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    20
    TargetMol | Inhibitors_Agonists
Lusaperidone
R107474
T11894214548-46-6In house
Lusaperidone (R107474) is a potent α2-adrenergic receptor antagonist, a potential radioligand for the α (2)-adrenergic receptor, with inhibitory effects on α2A and α2C, with Ki values of 0.13 and 0.15 nM, respectively.
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6-8 weeks
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SB 243213
T37816200940-22-3In house
SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders.
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7-10 days
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ly 344864 hydrochloride
T412951217756-94-9In house
LY 344864 hydrochloride is a selective receptor agonist with an affinity of 6 nM (Ki) at the 5-HT1F receptor.
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6-8 weeks
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Repinotan
BAY x 3702 free base
T61934144980-29-0In house
Repinotan (BAY x 3702 free base) is an orally active, selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), exhibits neuroprotective activity, counteracts morphine-induced depression of ventilation in anesthetized rats, and may be used in studies of acute ischemic stroke and traumatic brain injury.
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6-8 weeks
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Sarizotan 2HCl
T70044L177976-12-4In house
Sarizotan 2HCl is an hERG channel inhibitor and 5-hydroxytryptamine 5-HT1A receptor agonist with potential antidepressant effects for the study of Parkinsonian movement disorders.
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Chlorprothixene
Truxal, Taractan, Clorprotixeno
T0074113-59-7
Chlorprothixene (Truxal) is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized.
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Iloperidone
HP 873
T1539133454-47-4
Iloperidone (HP 873) is an atypical antipsychotic agent that is used for treatment of schizophrenia.
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AS19
T103801000578-26-6
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM) with demonstrated selectivity for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM, and 98.5 nM, respectively).
  • Inquiry Price
6-8 weeks
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Frovatriptan succinate hydrate
Frovelan, Frova
T11326158930-17-7
Frovatriptan succinate hydrate (Frova) is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and phonophobia. Frovatriptan succinate hydrate can also be used as in mini-prophylaxis in menstrual migraine. Frovatriptan succinate hydrate is a potent, high affinity, selective and orally active 5-HT1B, HT1D receptor agonist and a moderately potent 5-HT7 receptor agonist, with pKi values of 8.6, 8.4, and 6.7, respectively.
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JNJ-18038683
T11720851376-05-1
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist with pKis of 8.19 and 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.
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sb 243213 hydrochloride
T12859200940-23-4
SB 243213 hydrochloride is an orally active, selective, high-affinity antagonist of the 5-hydroxytryptamine (5-HT)2C receptor (pKi of 9.37 and pKb of 9.8), with an improved anxiolytic profile and potential for treating schizophrenia and motor disorders.
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1-2 weeks
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sb 243213 dihydrochloride
T12859L1780372-25-9
SB 243213 dihydrochloride is an orally active, selective, and high-affinity antagonist of the 5-hydroxytryptamine (5-HT)2C receptor, with a pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor.
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1-2 weeks
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Iloperidone hydrochloride
T228581299470-39-5
Iloperidone hydrochloride is a D(2) 5-HT(2) receptor antagonist. It is also an atypical antipsychotic for the treatment of schizophrenia symptoms.
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1-2 weeks
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ST1936
ST 1936
T233961210-81-7
ST1936 (ST 1936 oxalate) is a selective and highly potent 5-HT6 receptor agonist that inhibits human 5-HT6, 5-HT7 and 5-HT2B receptors by fully activating cloned human 5-HT6 receptors. body to stimulate cAMP, Ca2+, ERK1 2 and Fyn kinase.
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6-8 weeks
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ly 344864
LY344864
T2344186544-26-3
LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
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4-6 weeks
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rs 64459-193
RS64459-193, RS-64459-193
T34415123882-89-3
RS 64459-193 has a high affinity for the 5-HT1A binding site.
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6-8 weeks
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5-hydroxy-Nω-methyl Tryptamine (oxalate)
T3721215558-50-6
5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants. It is an agonist of the 5-HT receptor subtype 5-HT7 (IC50 = 23 pM in a radioligand binding assay). 5-hydroxy-Nω-methyl Tryptamine increases intracellular cyclic AMP production in HEK293 cells expressing 5-HT7 (EC50 = 22 nM). It inhibits serotonin uptake in HEK293 cells expressing human serotonin transporters (IC50 = 490 nM). Elevated levels of urinary 5-hydroxy-Nω-methyl tryptamine have been found in patients with schizophrenia, depression, and epilepsy.
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    Metergoline
    Methergoline, Liserdol
    T400817692-51-2
    Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.
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    Sarizotan
    EMD 128130
    T40439351862-32-3
    Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.
      7-10 days
      Inquiry
      GSK163090
      TQ0311844903-58-8
      GSK163090 is a specific and orally active 5-HT1A B D receptor antagonist (pKis: 9.4 8.5 9.7, and 6.3 6.7 for 5-HT1A B D, and dopamine D2 D3).
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