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hce2

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
  • Natural Products
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    TargetMol | Natural_Products
Corylifol A
Corylinin
T4S0145775351-88-7
1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.
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Alisol G
25-Anhydroalisol A, Alisol-G
TQ0249155521-46-3
Alisol G (25-Anhydroalisol A) is isolated from Rhizoma Alismatis and exhibits hCE2 inhibitory effects.
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