gondii — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN7103	13,21-Dihydroeurycomanone	Pasakbumin C	Anti-infection , Parasite
	13,21-Dihydroeurycomanone (Pasakbumin C) is a natural product isolated from the root of Eurycoma longifolia with antiparasitic activity such as Plasmodium falciparum and Toxoplasma gondii.		Anti-infection , Parasite
T1172	Diclazuril	R-64433	Antibiotic , Parasite
	Diclazuril (R-64433) is a coccidiostat.		Antibiotic , Parasite
T7943	Fluphenazine decanoate		Dopamine Receptor
	Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.		Dopamine Receptor
T36692	Fanotaprim		DHFR
	Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o...		DHFR
T72081	CpCDPK1/TgCDPK1-IN-2		Parasite
	CpCDPK1/TgCDPK1-IN-2 is a dual inhibitor of CpCDPK1 and TgCDPK1 with IC50 values of 12 and 5 nM for CpCDPK1 and TgCDPK1, respectively.CpCDPK1/TgCDPK1-IN-2 can be used in the study of diseases associated with infection of...		Parasite
T0819	Spiramycin	Espiramicin,Sequamycin,Rovamycin,Provamycin,Formacidine	Antibacterial , Antibiotic , Parasite
	Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caus...		Antibacterial , Antibiotic , Parasite
T21687	Conoidin A		Parasite
	Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation ...		Parasite
T61671	MMV687807
	MMV687807 is a potent anthelmintic compound exhibiting strong efficacy against Toxoplasma gondii (T. gondii). It demonstrates an IC50 value of 0.15 μM and a CC50 value of 1.69 μM [1].
T29003	TRC-19
	TRC-19 is a potent and selective inhibitor of Toxoplasma gondii dihydrofolate reductase. TRC-19 shows an IC50 of 9 nM and 89-fold selectivity in favor of Toxoplasma gondii dihydrofolate reductase.
T11846	LHVS		Cysteine Protease
	LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor.		Cysteine Protease
T40191	17-GMB-APA-GA
	17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection.
T69311	GW300657X
	GW300657X is a small molecule inhibitor that blocks toxoplasma gondii rhoptry kinase 18 and maintains moderate CDK2-cyclin A inhibitory activity.
T76121	Phosphoglucomutase		Endogenous Metabolite
	Phosphoglucomutase promotes cyst development in Toxoplasma gondii. Deficiency of Phosphoglucomutase causes metabolic disorders.		Endogenous Metabolite
T61114	Anti-Trypanosoma cruzi agent-2
	Anti-Trypanosoma cruzi agent-1 (Compd 3b), selective compound against NINOA trypomastigote (IC 50 = 0.51 μM) and INC-5 epimastigote form (IC 50 = 3.06 μM), posseses anti- T. gondii activity [1].
T83881	4-(3,4-Difluorobenzo)curcumin	CDF
	4-(3,4-Difluorobenzo)curcumin (CDF) is a semisynthetic coumarin noted for its antiparasitic and anticancer properties. It effectively reduces the population of Vero cells infected by T. gondii promastigotes and amastigot...
T17257	WR99210		DHFR , Antifolate , Antibacterial
	WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P. vivax and P. falciparum strains (including P. falciparum s...		DHFR , Antifolate , Antibacterial
T35750	Trypacidin
	Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, re...
T38269	Purfalcamine
	Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes mala...