glycohydrolase

Oenothein B is a specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B shows antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties.

Endo-1,4-β-xylanase (Xylanase), a glycoside hydrolase enzyme that degrades arabinoxylan (AX), is commonly utilized in biochemical research. It specifically hydrolyzes the β-xylosidic bonds linking two d-xylopyranosyl residues in a β-(1,4) configuration [1].

COH34 analog 1 is a COH34 oxidation analogue that can be used to synthesize active compounds.

PDD00031705 is a benzimidazolone core, cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.

PARG-IN-7 (Example 38) is a Poly ADP-ribose glycohydrolase (PARG) inhibitor with an IC50 of less than 0.1 μM. It reduces the viability of HCC1806-XRCC1 knockdown (KD) cells, exhibiting an IC50 of less than 1 μM. PARG-IN-7 is applicable in cancer research.

MDOLL-0286 is a selective inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), specifically targeting ARH3 with an IC50 value of 2.3 μM. It inhibits the poly(ADP-ribose) hydrolytic activity of ARH3 on cellular substrates and can suppress the DNA damage response. MDOLL-0286 is applicable in cancer research.

PDD00031704 is an inhibitor of poly (ADP-ribose) glycohydrolase (PARG), with an IC50 greater than 60 µM.

PDD00017272 (34f) is a potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), exhibiting an EC50 value of 4.8 nM in biochemical assays and 9.2 nM in cellular POM.

PDD00017238 demonstrates a robust inhibitory effect on Poly(ADP-ribose) Glycohydrolase (PARG), displaying EC50 values of 40 nM in biochemical assay and 55 nM in cell POM assessment.

pNP-ADPr is a colorimetric substrate used in continuous activity assays for Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3), aiding research on poly(ADP-ribose) polymerase (PARP) enzymes.

JA2131, a small molecular inhibitor targeting Poly(ADP-ribose) Glycohydrolase (PARG), has an IC50 value of 0.4 μM, modulates DNA damage responses, induces replication fork stalling, and leads to cancer cell death.

TFMU-ADPr serves as a versatile substrate for assessing poly(ADP-ribose) glycohydrolase (PARG) activity, enabling direct measurement of total PAR hydrolase activity through the liberation of a fluorophore. Exhibiting exceptional reactivity, generality, stability, and usability, TFMU-ADPr is an effective tool for evaluating small-molecule inhibitors and investigating the regulation of ADP-ribosyl catabolic enzymes in vitro [1].

PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity.

COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.

PARG-IN-6 (Compound 2) is an orally bioavailable PARG inhibitor with an IC50 of 0.3 nM. It exhibits significant anticancer activity against cancer cells, with an IC50 of 0.0368 μM for HCC1395 cells. PARG-IN-6 shows potential for research in colon cancer, appendiceal cancer, and pancreatic cancer.

Etidaligide sodium is a DNA repair inhibitor designed to prevent the repair of DNA damage in tumor cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase, enzymes that induce the phosphorylation of H2AX and the paralyzation of proteins.

Etidaligide is a DNA repair inhibitor designed to prevent the repair of DNA damage in tumor cells. It also activates DNA-dependent protein kinases (DNA-PK) and poly (ADP-ribose) polymerases, enzymes that promote the phosphorylation of H2AX and the parylation of proteins.

PDD00017273 is a radiosensitizing PARG) inhibitor with antitumor or activity for the study of epithelial ovaries.

Ethacridine lactate (Acrinol) is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.

RBPI-3 is a canonical poly(ADP-ribose) glycohydrolase.

ATPase-IN-2 is an effective bacterial F1F0-ATPase inhibitor. It interferes with energy metabolism by blocking ATP synthesis, used for developing novel antibiotics against drug-resistant pathogens.

TFMU-ADPr triethylamine, a versatile substrate for evaluating poly(ADP-ribose) glycohydrolase (PARG) activity, enables direct measurement of total PAR hydrolase activity through the liberation of a fluorophore. With outstanding reactivity, generality, stability, and usability, it serves as an essential tool for the in vitro assessment of small-molecule inhibitors and exploration of the regulation of ADP-ribosyl catabolic enzymes [1].

Carba-NAD sodium is a carbocyclic analog of NAD+ and is a good competitive inhibitor of calf spleen NAD+ glycohydrolase.