fucosyltransferase

Fucosyltransferase 3 (EC:2.4.1.65, FUT3, FT3B) exhibits potent α 1-3 and α 1-4 fucosyltransferase activity.

Fucosyltransferase 5 (EC:2.4.1.65, Fucosyltransferase 5, Fucosyltransferase V) is responsible for the final step in the synthesis of Lex, sialy-Lex, and Lea antigens.

Focusyltransferase 7 (FUT7) is a Golgi stack membrane protein. It catalyzes the final fucosylation step in the synthesis of Lewis antigens, resulting in the production of the specific glycosylated product sialyl Lewis X (sLeX). FUT7 is involved in catalyzing the α-1,3 glycosidic bond, which is crucial for sialyl Lewis X antigen expression.

Fucosyltransferase 11 (EC:2.4.1.-, FUT11) attaches α-L-fucose to glycoprotein substrates, specifically on asialoglycoprotein glycans and biantennary N-glycan acceptors. This enzyme is significant in the field of oncology.

Fucosyltransferase 2 (EC:2.4.1.69; FUT2) attaches fucose to the terminal galactose of a type I chain via an α1-2 linkage.

Fucosyltransferase 8 (EC:2.4.1.68; FUT8; α1-6FucT) is a glycosyltransferase that catalyzes the transfer of fucose residues from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans.

Fucosyltransferase 9 (EC:2.4.1.152, FUT9) catalyzes the final step in the biosynthesis of Lewis antigens by adding fucose to precursor polysaccharides. FUT9 synthesizes the LeX oligosaccharide (CD15).

Protein O-Fucosyltransferase 1 (EC:2.4.1.221; POFUT1) is a glycosyltransferase characterized by cysteine-rich motifs serving as receptor sugars and GDP as the donor.

Fucosyltransferase 6 is an enzyme responsible for the expression of the tetrasaccharide Sialyl-Lewis x (sLex, CD15s) on the surface of leukocytes. The sLex structure is crucial for E-selectin-mediated leukocyte rolling, which is associated with leukocyte extravasation from blood vessels.