excipient

ALC-0159 is a polyethylene glycol (PEG) lipid conjugate that could be used as a vaccine excipient[1].

mRNA-Encapsulating Lipid Excipient 1 (Compound 2), a thiocarbamate-based ionizable lipid, serves as an excipient in the formulation of mRNA-encapsulating lipid nanoparticles [1].

Isomalt (Palatinitol) is a mixture of 1,6-mannitol glucopyranoside and 1,6-sorbitol glucopyranoside

Gelucire 44/14 (Gelucire 14/44) acts as a nonionic surface-active excipient and improves fat absorption in rats with impaired lipolysis.

N,N-Dimethylacetamide (DMAc) is a drug excipient with blood-brain barrier permeability and anti-inflammatory activity, acting through inhibition of the NF-κB signaling pathway. N,N-Dimethylacetamide can reduce endotoxin-induced inflammatory responses in vivo.

Sodium dodecyl sulfate(Sodium lauryl sulfate) is a pharmaceutical excipient that is biologically inactive and improves the stability, solubility and processability of pharmaceutical preparations.

Castor oil (Xenaderm) is a vegetable oil pressed from the seeds of the castor bean, Ricinus communis, used as a laxative and as an excipient in medicinally.

Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative.

Triton X-100 is a non-denaturing detergent that solubilizes lipid membranes. Triton X-100 is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Triton X-100 is listed as an excipient in certain vaccines including split virus influenza vaccines. Triton X-100 is a nonionic surfactant [1] [2].

Sorbitan monooleate is a pharmaceutical excipient, a lipophilic nonionic surfactant, and is often used as an emulsifier in cosmetics, food and pharmaceuticals.

Sucrose octasulfate, a sulfated oligosaccharide derivative, functions as an inhibitor of matrix metalloproteinases (MMPs). This compound stimulates somatostatin-like immunoreactivity (SLI) release from the stomach by directly targeting D cells in the gastric mucosa. By releasing endogenous gastric somatostatin, sucrose octasulfate promotes ulcer healing. It serves as a pharmaceutical excipient, significantly enhancing wound closure in neuroischemic diabetic foot ulcers and venous leg ulcers. Additionally, sucrose octasulfate is applicable in research related to chronic wound healing.

4-Chloro-2-methylphenol is an antimicrobial agent used as a pharmaceutical excipient.

Poloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice.

Poly(acrylic acid) serves as an effective corrosion inhibitor for pure cast aluminium in acidic environments through its adsorption onto the metal's surface. Additionally, this compound functions as an excipient within the pharmaceutical industry, utilized in roles such as a coating material and release blocker. Pharmaceutical excipients, also known as pharmaceutical auxiliaries, are chemical substances employed in drug formulation alongside the active pharmaceutical ingredients to enhance the stability, solubility, and manufacturability of the products. These excipients also influence the absorption, distribution, metabolism, and elimination (ADME) processes of drugs [1] [2].

Cellulose can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1] .

Polyoxyethylene Sorbitan Monostearate, an ester derived from the saturated fatty acid stearic acid (C18:0), serves multiple roles in pharmaceutical formulations, including as a surfactant, emulsifier, solubilizer, and wetting agent. As a pharmaceutical excipient—an inert substance that enhances the stability, solubility, and processability of drug formulations—it plays a crucial role in affecting the absorption, distribution, metabolism, and elimination (ADME) processes of drugs [1] [2].

Maltodextrin (dextrose equivalent 16.5-19.5) serves as an excipient in pharmaceutical applications. Excipients, also known as pharmaceutical auxiliaries, are chemical substances utilized in drug formulation alongside active pharmaceutical ingredients. They primarily enhance the stability, solubility, and processability of drug preparations, while also influencing the absorption, distribution, metabolism, and elimination (ADME) of co-administered drugs [1].

Cholesterol-PEG-Folate (MW 2000), an excipient, facilitates the preparation of folate-conjugated PEG-liposomes [1].

Trisodium phosphate dodecahydrate serves as a corrosion inhibitor for iron in 0.1 M NaClO4 solutions, effective under both aerated and deaerated conditions. Additionally, it acts as an excipient in pharmaceutical formulations, functioning primarily as a pH regulator and buffer. These excipients, also known as pharmaceutical auxiliaries, are substances utilized in the pharmaceutical manufacturing process besides the active pharmaceutical ingredients. They are crucial for enhancing the stability, solubility, and processability of pharmaceutical products. Moreover, pharmaceutical excipients play a significant role in influencing the absorption, distribution, metabolism, and elimination (ADME) of co-administered drugs, thereby affecting their efficacy and safety [1] [2].

DMG-PEG 2000 (DMG-PEG2000) can be used for the preparation of lipid nanoparticles for the in vivo delivery of plasmid DNA via oral administration, enhancing the mucosal permeability and delivery efficiency of the nanoparticles. DMG-PEG 2000 can be used for the preparation of liposomes for siRNA transfection, improving transfection efficiency.

DSPE-Fluorescein is a phospholipid known for its excellent biocompatibility and pronounced amphiphilic properties, making it an ideal and prominent excipient or formulation agent in pharmaceuticals to achieve enhanced therapeutic outcomes. [DSPE-Fluorescein] is also applicable in research on drug delivery.

DSPE-Fluor 488 is a phospholipid known for its excellent biocompatibility and distinctive amphiphilic properties, making it an ideal form and excipient in pharmaceutical formulations for enhanced therapeutic outcomes. It is utilized in the study of drug delivery.

DOPE-PEG-FITC (MW 2000) is a phospholipid known for its excellent biocompatibility and significant amphiphilic properties, making it a primary and suitable excipient or formulation in drug delivery systems for enhanced therapeutic outcomes. Additionally, DOPE-PEG-FITC (MW 2000) is useful in research focused on drug delivery mechanisms.

DOPE-PEG-Azide (MW 1000) is a phospholipid known for its excellent biocompatibility and significant amphiphilic properties, making it a primary and suitable formulating agent or excipient in drug formulations for enhanced therapeutic outcomes. It is utilized in research focused on drug delivery.