esophagitis

Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain.

Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.

4-Hydroxy-hippuric acid is a secondary metabolite formed from polyphenol breakdown, detectable in humans. 4-Hydroxy-hippuric acid is associated with health conditions such as uremia and eosinophilic esophagitis, making it relevant for metabolic and clinical biomarker studies.

Dectrekumab (QAX576) is a humanized monoclonal antibody targeting IL-13 that reduces the number of eosinophils in the epithelium of patients with eosinophilic esophagitis (EoE), ameliorates transcriptional dysregulation associated with esophageal disease, and is indicated for use in the study of immune system disorders.

3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group

Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis

Vonoprazan-D3 is a deuterated compound of Vonoprazan. Vonoprazan (T8388) has a CAS number of 881681-00-1. Vonoprazan (T8388) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis

Vonoprazan-D4 is a deuterated compound of Vonoprazan. Vonoprazan (T8388) has a CAS number of 881681-00-1. Vonoprazan (T8388) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis

3-Methyl-L-histidine (Standard) is a reference standard for research and analysis in studies involving 3-Methyl-L-histidine. 3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. It is also a biomarker for the consumption of soy products. 3-Methylhistidine is a very strong basic compound (based on its pKa). 3-Methylhistidine exists in all eukaryotes, ranging from yeast to humans. In humans, 3-methylhistidine is involved in methylhistidine metabolism. 3-Methylhistidine, with regard to humans, has been found to be associated with several diseases such as diabetes mellitus type 2, eosinophilic esophagitis, and kidney disease; 3-methylhistidine has also been linked to the inborn metabolic disorder propionic acidemia. The measurement of 3-methylhistidine provides an index of the rate of muscle protein breakdown. 3-Methylhistidine is a product of peptide bond synthesis and methylation of actin and myosin. 3-Methylhistidine is a biomarker for meat consumption, especially chicken.Structure

Sanleng acid is an unsaturated fatty acid compound that can be isolated from the hexane extract of Magnolia sieboldii (MsHE). MsHE inhibits the expression of inflammatory mediators like COX-2 and pro-inflammatory cytokines such as TNF-α and IL-1β, while enhancing the expression of tight junction proteins (claudin-4, claudin-5) to protect epithelial cell barrier function, thereby exhibiting anti-inflammatory activity. This compound may be relevant for research related to reflux esophagitis (RE).