enterovirus 71 (ev71)

Rupintrivir (AG7088) is an antiviral agent and an irreversible inhibitor targeting human rhinovirus 3C protease (EC50 = 0.023 μM), featuring high selectivity and immunomodulatory activity, capable of effectively inhibiting multiple HRV serotypes as well as EV71 and EV-D68 replication, commonly used for research on viral infection mechanisms.

Norwogonin (5,7,8-Trihydroxyflavone), isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).

Vapendavir is a potent enteroviral capsid binder. Vapendavir has an effective antiviral activity for enterovirus 71 replication (EC50: 0.5-1.4 μM in different EV71 strains).

DTriP-22 is an effective, low-toxicity inhibitor of enterovirus 71 3D polymerase (EV71 3D polymerase). It exhibits broad-spectrum antiviral activity against RNA viruses, particularly picornaviruses, excluding EV71, but is ineffective against DNA viruses. By specifically inhibiting viral RNA synthesis, DTriP-22 acts at the early stage of viral replication and is useful for anti-enterovirus research.

Methyl 3,4-Dihydroxyphenylacetate is an effective enterovirus 71 (EV71) inhibitor capable of suppressing EV71 replication in rhabdomyosarcoma (RD) cells, exhibiting antiviral activity.

DMA-135 hydrochloride (DMA-135 HCl) Antivirally active compounds that target RNA and inhibit enterovirus type 71 (EV71) IRES-dependent translation and replication.DMA-135 hydrochloride can be used in the study of enteroviral infections.

Antiviral Agent 23, an effective inhibitor of enterovirus 71 (EV71) with an EC50 value of 94 nM, also exhibits potent suppression of METTL3/METTL14 activity. This compound is employed in the research of infections.

ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that blocks EV71/CVA16 replication and virus-induced pyroptosis linked to viral pathogenesis. It effectively prevents EV71 infection in neonatal and young mice in animal models and can be used to study viral infections such as hand, foot, and mouth disease (HFMD) [1].

Anti-Enterovirus 71 VP4 Antibody (3E202) is a monoclonal antibody targeting EV71 (Enterovirus 71) VP4, which is a mouse-derived antibody.