dhpg

DHPG ((RS)-3,5-DHPG) is an effective antagonist of mGluR linked to phospholipase D. As an amino acid, it serves as a selective and potent agonist for Group I mGluR (mGluR 1 and mGluR 5) without affecting Group II or Group III mGluRs.

(S)-3,5-DHPG is a weak but selective agonist of group I metabotropic glutamate receptors with Ki values of 0.9 μM for mGluR1a and 3.9 μM for mGluR5a. (S)-3,5-DHPG demonstrates anxiolytic activity in hypoxia-exposed rats, supporting its application in neuropharmacological studies of glutamatergic signaling, stress responses, and anxiety-related behaviors.

ACDPP is a specific antagonist of metabotropic glutamate receptor 5 (mGluR5) that partially blocks the DHPG-induced increase of fragile X mental retardation protein (FMRP), ACDPP is used as a pharmacological tool in neuroscience research to study group I mGluR signaling, synaptic plasticity, and molecular mechanisms underlying fragile X syndrome.

Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.