dbh

Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15/1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.

4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica keiskei root, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.

Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM.

Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.

DBHDA is a reagent to convert a Cys into a Dha moiety by reacting with a C-terminal Cys residue and thus allowing the use of recombinant Ubl G76C mutants to prepare probes.

(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively.The affinity of Nepicastat for twelve other enzymes and thirteen neurotransmitter receptors is negligible.

Clopidogrel-related Compound B hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T125846 and the CAS number is 144750-52-7.

Bad BH3 (mouse) is a bioactive peptide derived from the BH3 domain (a death domain) of Bad, comprising amino acid residues 140 to 165, and functions by binding to bcl-2.

Bid BH3 (80-99) is a biologically active peptide and a pro-apoptotic member of the 'BH3-only' (BOPS) subset within the BCL-2 protein family, crucial in apoptosis regulation. It interacts with Bcl-2, Bax, and Bak to initiate their activation or inactivation, inducing cell death. Bid translocates from the cytosol to the mitochondrial membrane as part of its mechanism. Pyroglutamyl (pGlu) peptides, which can arise from Glutamine (Q) or Glutamic acid (E) at the N-terminus, have a hydrophobic γ-lactam ring that enhances stability and provides resistance to gastrointestinal proteases. These peptides are recognized variants in peptide analyses, including HPLC purity assessments.

FAM-labeled Bid BH3 (80-99) is a biologically active peptide featuring a 5-FAM label at its N-terminus.

r8 Bid BH3, a biologically active peptide, is a pro-apoptotic member of the "BH3-only" subset within the BCL-2 family proteins, pivotal in regulating apoptosis. This compound exhibits lethality towards Bcl-2-expressing human leukemia cell lines, indicating its promise as a potential cancer therapeutic. The peptide is conjugated with poly-D-arginine (denoted by rrrrrrrr), enhancing cellular uptake.

Bid BH3 peptide, a small peptide derived from the Bid protein, binds to and activates the pro-apoptotic proteins Bax and Bak, leading to mitochondrial outer membrane permeabilization (MOMP) and cell apoptosis (apoptosis). This peptide is utilized in research on mitochondrial bioenergetics.

Bid BH3 (80-99) (acetate) is a biologically active peptide. As a pro-apoptotic member of the BCL-2 protein family’s "only BH3" (BOPS) subset, BID plays a crucial role in the regulation of apoptosis. It is reported that Bid is the first BOP to bind and activate Bcl-2, Bax, and Bak. Acting as a death-inducing ligand, Bid moves from the cytosol to the mitochondrial membrane to deactivate Bcl-2 or activate Bax. When glutamine (Q) or glutamic acid (E) is located at the sequence's N-terminus, they naturally convert to pGlu. The hydrophobic γ-lactam ring of pGlu is thought to enhance peptide stability against gastrointestinal proteases. Consequently, pyroglutamyl peptides are considered a regular subset of such peptides and are included as part of peptide purity in HPLC analysis.

Bid BH3-Gly-r8 is a variant of Bid BH3 linked with eight arginines. It shows no difference in apoptotic effects compared to the unmodified peptide homologue, Bid BH3. Both Bid BH3-Gly-r8 and Bid BH3 exhibit high affinity for Bax and Bcl-2. This compound is applicable in tumor research.

7-APDB hydrochloride is a benzofuran compound utilized in research related to neurological disorders.

Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH) and a concentration-dependent dual inhibitor of P-gp and BCRP, with IC50 values of 73.8 μM and 17.0 μM, respectively.

FLA-63 is a dopamine-beta-hydroxylase (DBH)-inhibitor and an inhibitor of the last step of noradrenaline biosynthesis.

3-Allylphenol is an inhibitor of dopamine β-hydroxylase (DBH; Ki = 12 mM).