dbco acid

DBCO-acid is utilized in the synthesis of ADC linker DBCO-NHS ester and drug-linker conjugates DBCO-PEG-MMAE[1].

DBCO acid 2 is a Click Chemistry intermidate used for antibody-drug conjugates.

DBCO-C6-acid is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) and carmaphycin analogues[1].

DBCO-Amide-PEG5-acid is a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-PEG4-C2-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG13-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG3-acid, a PEG-based linker for PROTACs, joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG7-acid is a PEG-based linker for PROTACs, connecting two essential ligands vital for forming PROTAC molecules and enabling selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-PEG1-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG12-acid is a PEG-based linker for PROTACs that connects two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-PEG2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, and enables selective protein degradation via the ubiquitin-proteasome system within cells.

DBCO-PEG8-acid, a PEG-based linker for PROTACs, joins two essential ligands critical for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-DBCO-N-bis(PEG2-C2-acid) is a polyethylene glycol (PEG) linker commonly employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-PEG3-C1-acid serves as a linker for antibody-drug conjugates (ADCs), facilitating the strain-promoted azide-alkyne click reaction as a reaction handle.

DBCO-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-S-S-acid, a cleavable ADC linker for synthesizing antibody-drug conjugates (ADCs) [1], is a click chemistry reagent that features a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with Azide-containing molecules.

DBCO-PEG3-acid is a non-cleavable ADC linker featuring three PEG units, utilized for synthesizing antibody-drug conjugates (ADCs). This compound includes a DBCO group capable of participating in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing azide groups.

DBCO-PEG24-acid is a click chemistry reagent that serves as an analog of DBCO-acid featuring a PEG linker and a DBCO group. The DBCO group is typically utilized in copper-free click chemistry reactions due to its strain-promoted high energy. The hydrophilic polyethylene glycol (PEG) chain enhances water solubility. The terminal carboxylic acid group reacts with primary amine groups in the presence of activators (such as EDC or HATU), forming stable amide bonds. This compound is of reagent grade and strictly for research purposes.

Sulfo DBCO-PEG3-acid is a click chemistry reagent featuring an azide group. This compound is an analog of DBCO-acid, equipped with a PEG linker and a DBCO moiety. The DBCO group, known for its strain-promoted high-energy state, is commonly utilized in copper-free click reactions. The hydrophilic polyethylene glycol chain and the sulfonyl group enhance its water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (such as EDC or HATU) to form stable amide bonds. This reagent is for research use only and is of reagent grade.

DBCO-PEG2-C2-acid serves as an ADC Linker, facilitating the synthesis of Antibody-Drug Conjugates (ADCs).

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

Azido-PEG13-acid is a PEG-based PROTAC linker useful in the synthesis of PROTAC molecules. It acts as a click chemistry reagent containing an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules featuring alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition reaction (SPAAC) with molecules that have DBCO or BCN groups.

Azido-PEG7-acid is a PROTAC linker belonging to the PEG class, used in the synthesis of PROTAC molecules. It functions as a click chemistry reagent, incorporating an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules that possess DBCO or BCN groups.

3-Azidopropionic Acid Sulfo-NHS Ester is a water-soluble compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the p