da6

Diethyl aminoethyl hexanoate citrate (2-Diethylaminoethyl hexanoate citrate) is a compound that is widely used as a plant growth regulator stimulates the regeneration of adventitious buds.

RGD-DA6 is an αvβ3-targeting ligand composed of RGDfK (an RGD peptide targeting integrin αvβ3), DOTADG, d-Glu, Lys, AMBA, and IPBA. Through radiolabeling, RGD-DA6 forms an αvβ3-targeted radioligand for high-contrast tumor imaging and improved anticancer efficacy.

AL-GDa62, a potential synthetic lethal agent for gastric cancer treatment, demonstrates efficacy with EC50 values of 3.2 μM in MCF10A-WT (wild-type) isogenic mammary epithelial cells and 2 μM in MCF10A-CDH1 -/- cells [1].

DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels.

Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).

Lipid A6 is a biodegradable alkyne lipid used in the synthesis of lipid-like nanoparticles (LNPs) for mRNA delivery.

Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM.

Recflavone( DA-6034) is a synthetic derivative of eupatilin and flavonoids that have anti-inflammatory effects against inflammatory bowel disease.